ReviewEuropean journal of applied physiology2014
Blood pressure regulation X: what happens when the muscle pump is lost? Post-exercise hypotension and syncope.
Review in European journal of applied physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 81 citations in OpenAlex.
- Acute effects of bolus water intake on post-exercise orthostatic hypotension and cardiovascular hemodynamics.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025Trial
- Salt Loading Blunts Central and Peripheral Postexercise Hypotension.Medicine and science in sports and exercise · 2020Trial
- Can Heart Rate Variability Determine Recovery Following Distinct Strength Loadings? A Randomized Cross-Over Trial.International journal of environmental research and public health · 2019Trial
- Suspension syndrome: a potentially fatal vagally mediated circulatory collapse-an experimental randomized crossover trial.European journal of applied physiology · 2019Trial
- Mast cell degranulation and de novo histamine formation contribute to sustained postexercise vasodilation in humans.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Trial
- A single dose of histamine-receptor antagonists before downhill running alters markers of muscle damage and delayed-onset muscle soreness.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Trial
- The influence of high-intensity compared with moderate-intensity exercise training on cardiorespiratory fitness and body composition in colorectal cancer survivors: a randomised controlled trial.Journal of cancer survivorship : research and practice · 2016Trial
- Effect of antioxidants on histamine receptor activation and sustained postexercise vasodilatation in humans.Experimental physiology · 2015Trial
- Study protocol for a randomized controlled trial of a culturally adapted cardiovascular dance intervention in Mapuche women with obesity.Frontiers in public health · 2026Article
- High-intensity exercise training mitigates post-exercise orthostatic hypotension in men.European journal of applied physiology · 2026Article
- Motor induced syncope after cerebral infarction: A case report and literature review.SAGE open medical case reports · 2025Article
- Ingesting carbonated water post-exercise in the heat transiently ameliorates hypotension and enhances mood state.Experimental physiology · 2024Article
- Interactive effects of exercise intensity and recovery posture on postexercise hypotension.American journal of physiology. Regulatory, integrative and comparative physiology · 2024Article
- A century of exercise physiology: concepts that ignited the study of human thermoregulation. Part 3: Heat and cold tolerance during exercise.European journal of applied physiology · 2024Review
- Cardiovascular responses to leg-press exercises during head-down tilt.Frontiers in sports and active living · 2024Article
- A century of exercise physiology: concepts that ignited the study of human thermoregulation. Part 1: Foundational principles and theories of regulation.European journal of applied physiology · 2023Review
- Critical power is a key threshold determining the magnitude of post-exercise hypotension in non-hypertensive young males.Experimental physiology · 2023Article
- Comparisons Between Normobaric Normoxic and Hypoxic Recovery on Post-exercise Hemodynamics After Sprint Interval Cycling in Hypoxia.Frontiers in physiology · 2022Article
- Effect of an Ultra-Endurance Event on Cardiovascular Function and Cognitive Performance in Marathon Runners.Frontiers in physiology · 2022Article
- Histamine, mast cell tryptase and post-exercise hypotension in healthy and collapsed marathon runners.European journal of applied physiology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Syncope which occurs suddenly in the setting of recovery from exercise, known as post-exercise syncope, represents a failure of integrative physiology during recovery from exercise. We estimate that between 50 and 80% of healthy individuals will develop pre-syncopal signs and symptoms if subjected to a 15-min head-up tilt following exercise. Post-exercise syncope is most often neurally mediated syncope during recovery from exercise, with a combination of factors associated with post-exercise hypotension and loss of the muscle pump contributing to the onset of the event. One can consider the initiating reduction in blood pressure as the tip of the proverbial iceberg. What is needed is a clear model of what lies under the surface; a model that puts the observational variations in context and provides a rational framework for developing strategic physical or pharmacological countermeasures to ultimately protect cerebral perfusion and avert loss of consciousness. This review summarizes the current mechanistic understanding of post-exercise syncope and attempts to categorize the variation of the physiological processes that arise in multiple exercise settings. Newer investigations into the basic integrative physiology of recovery from exercise provide insight into the mechanisms and potential interventions that could be developed as countermeasures against post-exercise syncope. While physical counter maneuvers designed to engage the muscle pump and augment venous return are often found to be beneficial in preventing a significant drop in blood pressure after exercise, countermeasures that target the respiratory pump and pharmacological countermeasures based on the involvement of histamine receptors show promise.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.