Evidence map›Paper›PMID 24196586›Full record

ArticleChemical communications (Cambridge, England)2014

Investigating the reactivities of a polyketide synthase module through fluorescent click chemistry.

Amanda Jane Hughes, Matthew R Tibby, Drew T Wagner, Johnathan N Brantley, Adrian T Keatinge-Clay

Abstract read
In one paragraph

Article in Chemical communications (Cambridge, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Current State-of-the-Art Toward Chemoenzymatic Synthesis of Polyketide Natural Products.Chembiochem : a European journal of chemical biology · 2023
    Review
  3. Review
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Amanda Jane HughesDepartment of Chemistry and Biochemistry, The University of Texas at Austin, 1 University Station A5300, Austin, TX, USA. adriankc@utexas.edu.
Matthew R Tibby
Drew T Wagner
Johnathan N Brantley
Adrian T Keatinge-Clay

Funding

Determining the Architectures and Activities of Polyketide Synthase ModulesR01GM106112 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI KEATINGE-CLAY, ADRIAN TRISTAN · 2013 to 2025
$3.9M
NIGMS NIH HHS GM106112NIGMS NIH HHS R01 GM106112
6 · The paper itself

Abstract

A method for monitoring in vitro polyketide synthesis has been developed whereby nonchromophoric polyketide products are made brightly fluorescent in a simple, rapid, inexpensive, and bioorthogonal manner through CuAAC with a sulforhodamine B azide derivative.

Indexed as

Click ChemistryFluorescent DyesRhodaminesAzidesCatalysisCopperPolyketidesPolyketide SynthasesAzidesCopperFluorescent Dyeslissamine rhodamine BPolyketidesPolyketide SynthasesRhodamines

Identifiers

PMID24196586
PMCPMC3999232

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.