ArticleScientific reports2013
Enhanced transcription and translation in clay hydrogel and implications for early life evolution.
Article in Scientific reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 105 citations in OpenAlex.
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- From peptides to DNA: All required steps can be catalyzed.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- RNA-Based Communication in Heterogeneous Populations of Cell Mimics.ACS synthetic biology · 2026Article
- DNA-based hydrogels: Ideal biomaterials for cartilage organoids.Fundamental research · 2025Review
- DNA-based hydrogels for bone regeneration: A promising tool for bone organoids.Materials today. Bio · 2025Review
- Cell-Free Gene Expression: Methods and Applications.Chemical reviews · 2025Review
- On the Origin of Life on Earth: The Nanozymes Hypothesis, and More.Research (Washington, D.C.) · 2025Review
- DNA and the origins of life in micaceous clay.Biophysical journal · 2022Article
- Hydrogels as functional components in artificial cell systems.Nature reviews. Chemistry · 2022Review
- Perpetuating enzymatically induced spatiotemporal pH and catalytic heterogeneity of a hydrogel by nanoparticles.Chemical science · 2022Article
- Microfluidic Production of Porous Polymer Cell-Mimics Capable of Gene Expression.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Enhanced Ribozyme-Catalyzed Recombination and Oligonucleotide Assembly in Peptide-RNA Condensates.Angewandte Chemie (International ed. in English) · 2021Article
- Smart and Functionalized Development of Nucleic Acid-Based Hydrogels: Assembly Strategies, Recent Advances, and Challenges.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Review
- Primitive Compartmentalization for the Sustainable Replication of Genetic Molecules.Life (Basel, Switzerland) · 2021Review
- Greenalite Nanoparticles in Alkaline Vent Plumes as Templates for the Origin of Life.Astrobiology · 2021Article
- Modularize and Unite: Toward Creating a Functional Artificial Cell.Frontiers in molecular biosciences · 2021Review
- Development, Preparation, and Biomedical Applications of DNA-Based Hydrogels.Frontiers in bioengineering and biotechnology · 2021Review
- Silk fibroin as an additive for cell-free protein synthesis.Synthetic and systems biotechnology · 2020Article
- The Oldest Highlands of Mars May Be Massive Dust Fallout Deposits.Scientific reports · 2020Article
- Clay nanolayer encapsulation, evolving from origins of life to future technologies.The European physical journal. Special topics · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In most contemporary life forms, the confinement of cell membranes provides localized concentration and protection for biomolecules, leading to efficient biochemical reactions. Similarly, confinement may have also played an important role for prebiotic compartmentalization in early life evolution when the cell membrane had not yet formed. It remains an open question how biochemical reactions developed without the confinement of cell membranes. Here we mimic the confinement function of cells by creating a hydrogel made from geological clay minerals, which provides an efficient confinement environment for biomolecules. We also show that nucleic acids were concentrated in the clay hydrogel and were protected against nuclease, and that transcription and translation reactions were consistently enhanced. Taken together, our results support the importance of localized concentration and protection of biomolecules in early life evolution, and also implicate a clay hydrogel environment for biochemical reactions during early life evolution.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.