Trial reportMedical science monitor : international medical journal of experimental and clinical research2013
Resistance circuit training reduced inflammatory cytokines in a cohort of male adults with Down syndrome.
Trial report in Medical science monitor : international medical journal of experimental and clinical research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 3 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Effectiveness of Resistance Training in People With Down Syndrome: Systematic Review and Meta-Analysis.Journal of applied research in intellectual disabilities : JARID · 2026Pooled it
- The intensity of exercise and inflammation markers in women with overweight & obesity: a systematic review and network meta-analysis.International journal of obesity (2005) · 2025Pooled it
- Understanding the effectiveness and underlying mechanisms of lifestyle modification interventions in adults with learning disabilities: a mixed-methods systematic review.Health technology assessment (Winchester, England) · 2025Pooled it
- A Short-Term Resistance Training Circuit Improved Antioxidants in Sedentary Adults with Down Syndrome.Oxidative medicine and cellular longevity · 2021Trial
- Plasma inflammatory biomarkers response to aerobic versus resisted exercise training for chronic obstructive pulmonary disease patients.African health sciences · 2016Trial
- Circuit resistance training attenuates acute exertion-induced reductions in arterial function but not inflammation in obese women.Metabolic syndrome and related disorders · 2015Trial
- Impact of Resistance Training on Body Composition and Physical Function in Individuals with Down Syndrome: A Meta-Analysis.Diagnostics (Basel, Switzerland) · 2024Review
- Immunological Response to Exercise in Athletes with Disabilities: A Narrative Review of the Literature.Healthcare (Basel, Switzerland) · 2023Review
- Resistance training and Down Syndrome: A narrative review on considerations for exercise prescription and safety.Frontiers in physiology · 2022Review
- Prescription and Effects of Strength Training in Individuals with Intellectual Disability-A Systematic Review.Sports (Basel, Switzerland) · 2021Review
- Effect of Resistance Exercise on the Lipolysis Pathway in Obese Pre- and Postmenopausal Women.Journal of personalized medicine · 2021Article
- Impact of aerobic versus resisted exercise training on systemic inflammation biomarkers and quality of Life among obese post-menopausal women.African health sciences · 2019Article
- Effect of startup circuit exercise on derivatives reactive oxygen metabolites, biological antioxidant potential levels and physical fitness of adolescents boys with intellectual disabilities.Journal of exercise rehabilitation · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIt is widely accepted that muscle strength plays a key role on functional tasks of daily living and employability in individuals with Down syndrome (DS). Recent studies have also reported resistance training may improve chronic inflammation in other clinical situations. This is the first study conducted to determine the effect of resistance circuit training on low-grade systemic inflammation in adults with DS. MATERIAL/
methodsA total of 40 young male adults with DS were recruited for the trial through different community support groups for people with intellectual disabilities and their families. They had medical approval for physical activity participation. Twenty-four were randomly assigned to perform resistance circuit training with 6 stations, 3 days per week for 12 weeks. Exercise intensity was based on function of the 8RM assessments. The control group included 16 age-, sex-, and BMI-matched adults with Down syndrome. Plasma levels of leptin, adiponectin, and TNF-a were assessed by commercial ELISA kits. C-reactive protein (CRP) was assessed by nephelometry. Body composition was also determined, measuring fat-free mass percentage and waist circumference (WC). This protocol was approved by our Institutional Ethics Committee.
resultsPlasma levels of leptin, TNF-a, and IL-6 were significantly decreased after the completion of the training program, as were fat-free mass and WC. No sports-related injuries or withdrawals from the program were reported during the entire study period. No changes were observed in the control group.
conclusionsResistance circuit training improved low-grade systemic inflammation in male sedentary adults with DS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.