ArticleJournal of dental research2014
Sodium fluoride inhibits MMP-2 and MMP-9.
Article in Journal of dental research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 101 citations in OpenAlex.
- Comparison of universal adhesives used in different etching modes on dentin bond strength: a systematic review and network meta-analysis.BMC oral health · 2026Pooled it
- Trial
- The impact of sodium fluoride addition to an adhesive system on micro tensile bond strength of ceramic occlusal veneer.Odontology · 2026Article
- Proteomic profile of the dentine pellicle modified with plant polyphenols and fluoride.Clinical oral investigations · 2026Article
- Efficacy of theaflavin-based dental varnishes against erosive demineralizatıon and matrix metalloproteinase expression.Odontology · 2026Article
- Saliva-Activated Nanohybrid Aggregates Are Rapid-Acting Agglutination Agents with Potent Anticaries Activity and Limited Toxicity.ACS pharmacology & translational science · 2025Article
- Do matrix metalloproteinase and cathepsin K inhibitors work synergistically to reduce dentin erosion?Journal of applied oral science : revista FOB · 2023Article
- Insight into the development of versatile dentin bonding agents to increase the durability of the bonding interface.Frontiers in dental medicine · 2023Review
- Effect of silver nanoparticles associated with fluoride on the progression of root dentin caries in vitro.PloS one · 2023Article
- Inhibition of Demineralization of Dentin by Fluoride-Containing Hydrogel Desensitizers: An In Vitro Study.Journal of functional biomaterials · 2022Article
- Matrix Metalloproteinases in Dental and Periodontal Tissues and Their Current Inhibitors: Developmental, Degradational and Pathological Aspects.International journal of molecular sciences · 2022Review
- Topical Agents for Nonrestorative Management of Dental Erosion: A Narrative Review.Healthcare (Basel, Switzerland) · 2022Review
- Potential of Fluoride-Containing Zinc Oxide and Copper Oxide Nanocomposites on Dentin Bonding Ability.Nanomaterials (Basel, Switzerland) · 2022Article
- Evaluation of Proanthocyanidin-based dentifrices on dentin-wear after erosion and dental abrasion -Journal of clinical and experimental dentistry · 2022Article
- Construction of a Microfluidic Platform With Core-Shell CdSSe@ZnS Quantum Dot-Encoded Superparamagnetic Iron Oxide Microspheres for Screening and Locating Matrix Metalloproteinase-2 Inhibitors From Fruits ofFrontiers in nutrition · 2022Article
- Concentration-Dependent Multi-Potentiality of L-Arginine: Antimicrobial Effect, Hydroxyapatite Stability, and MMPs Inhibition.Molecules (Basel, Switzerland) · 2021Article
- [Use of fluorides for caries prevention].Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz · 2021Review
- Dentifrices or gels containing MMP inhibitors prevent dentine loss: in situ studies.Clinical oral investigations · 2021Article
- Changes in Gene and Protein Expression of Metalloproteinase-2 and -9 and Their Inhibitors TIMP2 and TIMP3 in Different Parts of Fluoride-Exposed Rat Brain.International journal of molecular sciences · 2020Article
- In situ effect of a proanthocyanidin mouthrinse on dentin subjected to erosion.Journal of applied oral science : revista FOB · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The importance of fluoride (F) in preventing dental caries by favorably interfering in the demineralization-remineralization processes is well-established, but its ability to inhibit matrix metalloproteinases (MMPs), which could also help to prevent dentin caries, has not been investigated. This study assessed the ability of F to inhibit salivary and purified human gelatinases MMPs-2 and -9. Saliva was collected from 10 healthy individuals. Pooled saliva was centrifuged, and supernatants were incubated for 1 hr at 37°C and subjected to zymography. Sodium fluoride (50-275 ppm F) was added to the incubation buffer. The reversibility of the inhibition of MMPs-2 and -9 by NaF was tested by the addition of NaF (250-5,000 ppm F) to the incubation buffer, after which an additional incubation was performed in the absence of F. F decreased the activities of pro- and active forms of salivary and purified human MMPs in a dose-response manner. Purified gelatinases were completely inhibited by 200 ppm F (IC50 = 100 and 75 ppm F for MMPs-2 and -9, respectively), and salivary MMP-9 by 275 ppm F (IC50 = 200 ppm F). Inhibition was partially reversible at 250-1,500 ppm F, but was irreversible at 5,000 ppm F. This is the first study to describe the ability of NaF to inhibit MMPs completely.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.