ArticleMammalian genome : official journal of the International Mammalian Genome Society2013
Copy number variations of MICAL-L2 shaping gene expression contribute to different phenotypes of cattle.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed.
- Copy Number Variations of theGenes · 2025Article
- Copy number variations within fibroblast growth factor 13 gene influence growth traits and alternative splicing in cattle.Animal biotechnology · 2024Article
- Copy Number Variation of theAnimals : an open access journal from MDPI · 2022Article
- Copy Number Variations in theAnimals : an open access journal from MDPI · 2022Article
- Distribution of Copy Number Variation in SYT11 Gene and Its Association with Growth Conformation Traits in Chinese Cattle.Biology · 2022Article
- Genotype-by-environment interaction in Holstein heifer fertility traits using single-step genomic reaction norm models.BMC genomics · 2021Article
- Copy Number Variations and Expression Levels of Guanylate-Binding Protein 6 Gene Associated with Growth Traits of Chinese Cattle.Animals : an open access journal from MDPI · 2020Article
- CNV analysis of Meishan pig by next-generation sequencing and effects ofJournal of animal science and biotechnology · 2020Article
- Genomic copy number variation of the CHKB gene alters gene expression and affects growth traits of Chinese domestic yak (Bos grunniens) breeds.Molecular genetics and genomics : MGG · 2019Article
- Associations ofArchives animal breeding · 2019Article
- Copy number variation (CNV) in theArchives animal breeding · 2019Article
- Integrating CNVs into meta-QTL identified GBP4 as positional candidate for adult cattle stature.Functional & integrative genomics · 2018Article
- Copy Number Variations of KLF6 Modulate Gene Transcription and Growth Traits in Chinese Datong Yak (Bos Grunniens).Animals : an open access journal from MDPI · 2018Article
- Widespread modulation of gene expression by copy number variation in skeletal muscle.Scientific reports · 2018Article
- Overexpression of MICAL2, a novel tumor-promoting factor, accelerates tumor progression through regulating cell proliferation and EMT.Journal of Cancer · 2018Review
- Whole-genome sequencing reveals mutational landscape underlying phenotypic differences between two widespread Chinese cattle breeds.PloS one · 2017Article
- Genome-Wide Detection of CNVs and Their Association with Meat Tenderness in Nelore Cattle.PloS one · 2016Article
- Phenotypic variability of a terminal 7q deletion/8q duplication in Korean siblings.Annals of laboratory medicine · 2015Article
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9 authors.
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Abstract
Copy number variations (CNVs) recently have been recognized as an important source of genetic variability. Compelling evidence has indicated that CNVs are responsible for phenotypic traits by altering the copy numbers of functional genes. The molecule interacting with CasL-like protein 2 (MICAL-L2) gene plays a critical role in muscle fiber development and has been identified in the CNV region by comparative genomic hybridization array. In the present study, we detected the different distributions of MICAL-L2 gene copy numbers in four Chinese cattle breeds (QC, NY, LX, and CY) and investigated the functional effects of MICAL-L2 CNVs on the gene's expression level and the phenotypic traits in QC and NY cattle. The results showed that the copy number loss (relative to Angus cattle) was more frequent in CY than in the other breeds. The MICAL-L2 gene copy number presented a moderate negative correlation with the transcriptional expression in fetal skeletal muscles (P < 0.05). Statistical analysis revealed that the MICAL-L2 CNVs were significantly associated with body weight, body height, and body length of NY cattle in the early stages (6 and 12 months old), and the copy number loss showed better traits than the gain and/or median groups (P < 0.05). No significance was found at the late stages in QC (24 months old) and NY cattle (18 and 24 months old). These observations provided further insight into the associations between cattle CNVs and economic traits, suggesting that the CNVs may be considered promising markers for the molecular breeding of Chinese beef cattle.
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