ArticleMolecular endocrinology (Baltimore, Md.)2013
ATF3 expression in the corpus luteum: possible role in luteal regression.
Article in Molecular endocrinology (Baltimore, Md.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
- The roles of MAPK signaling pathway in ovarian folliculogenesis.Journal of ovarian research · 2025Review
- Transcriptional profiling of mucus production in rhesus macaque endocervical cells under hormonal regulation†.Biology of reproduction · 2024Article
- Neuregulin 1 Signaling Attenuates Tumor Necrosis Factor α-Induced Female Rat Luteal Cell Death.Endocrinology · 2024Article
- Unraveling the role of lipid droplets and perilipin 2 in bovine luteal cells.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024Article
- Luteal Lipid Droplets: A Novel Platform for Steroid Synthesis.Endocrinology · 2023Article
- Prostaglandin F2α regulates mitochondrial dynamics and mitophagy in the bovine corpus luteum.Life science alliance · 2023Article
- Article
- Deciphering the functional role of EGR1 in Prostaglandin F2 alpha induced luteal regression applying CRISPR in corpus luteum of buffalo.Biological research · 2021Article
- Bioactivity of recombinant hFSH glycosylation variants in primary cultures of porcine granulosa cells.Molecular and cellular endocrinology · 2020Article
- Trafficking of cholesterol from lipid droplets to mitochondria in bovine luteal cells: Acute control of progesterone synthesis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- Formation and characterization of lipid droplets of the bovine corpus luteum.Scientific reports · 2020Article
- Luteinizing hormone regulates the phosphorylation and localization of the mitochondrial effector dynamin-related protein-1 (DRP1) and steroidogenesis in the bovine corpus luteum.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- Yes-associated protein 1 is required for proliferation and function of bovine granulosa cells in vitro†.Biology of reproduction · 2019Article
- Influence of omega-3 fatty acids on bovine luteal cell plasma membrane dynamics.Biochimica et biophysica acta. Biomembranes · 2017Article
- Early transcriptome responses of the bovine midcycle corpus luteum to prostaglandin F2α includes cytokine signaling.Molecular and cellular endocrinology · 2017Article
- Activating transcription factor 3 promotes embryo attachment via up-regulation of leukemia inhibitory factor in vitro.Reproductive biology and endocrinology : RB&E · 2017Article
- Transcriptomes of bovine ovarian follicular and luteal cells.Data in brief · 2017Article
- Gene expression profiling of bovine ovarian follicular and luteal cells provides insight into cellular identities and functions.Molecular and cellular endocrinology · 2017Article
- Hypoglycosylated hFSH Has Greater Bioactivity Than Fully Glycosylated Recombinant hFSH in Human Granulosa Cells.The Journal of clinical endocrinology and metabolism · 2015Article
- Effects of IL8 and immune cells on the regulation of luteal progesterone secretion.Reproduction (Cambridge, England) · 2014Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
The present study investigated the induction and possible role of activating transcription factor 3 (ATF3) in the corpus luteum. Postpubertal cattle were treated at midcycle with prostaglandin F2α(PGF) for 0-4 hours. Luteal tissue was processed for immunohistochemistry, in situ hybridization, and isolation of protein and RNA. Ovaries were also collected from midluteal phase and first-trimester pregnant cows. Luteal cells were prepared and sorted by centrifugal elutriation to obtain purified small (SLCs) and large luteal cells (LLCs). Real-time PCR and in situ hybridization showed that ATF3 mRNA increased within 1 hour of PGF treatment in vivo. Western blot and immunohistochemistry demonstrated that ATF3 protein was expressed in the nuclei of LLC within 1 hour and was maintained for at least 4 hours. PGF treatment in vitro increased ATF3 expression only in LLC, whereas TNF induced ATF3 in both SLCs and LLCs. PGF stimulated concentration- and time-dependent increases in ATF3 and phosphorylation of MAPKs in LLCs. Combinations of MAPK inhibitors suppressed ATF3 expression in LLCs. Adenoviral-mediated expression of ATF3 inhibited LH-stimulated cAMP response element reporter luciferase activity and progesterone production in LLCs and SLCs but did not alter cell viability or change the expression or activity of key regulators of progesterone synthesis. In conclusion, the action of PGF in LLCs is associated with the rapid activation of stress-activated protein kinases and the induction of ATF3, which may contribute to the reduction in steroid synthesis during luteal regression. ATF3 appears to affect gonadotropin-stimulated progesterone secretion at a step or steps downstream of PKA signaling and before cholesterol conversion to progesterone.
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