ArticleSaudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association
Correlation between hepatitis B surface antigen titers and HBV DNA levels.
Article in Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- SASLT practice guidelines for the management of hepatitis B virus.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology AssociationGuideline
- Trial
- Hepatitis B virus quantitative surface antigen levels differ by genotype.Canadian liver journal · 2025Article
- Article
- Article
- A Predictive Model to Evaluate the HbeAg Positivity of Chronic Hepatitis B Virus Patients in Clinics: A Cross-Sectional Study.Medicina (Kaunas, Lithuania) · 2022Article
- Use of a Deep Learning Approach for the Sensitive Prediction of Hepatitis B Surface Antigen Levels in Inactive Carrier Patients.Journal of clinical medicine · 2022Article
- The role of quantitative HBsAg in patients with HBV DNA between 2000-20,000 IU/ml.Wiener klinische Wochenschrift · 2021Article
- Quantitative HBsAg and Qualitative HBeAg Predicts Intrauterine Placental Infection and Umbilical Blood Cord in Pregnant Women.Journal of family & reproductive health · 2020Article
- Analytical performance of three diagnostic reagents for HBsAg on an automatic ELISA analyzer.Journal of clinical laboratory analysis · 2018Article
- Observational
- Cytotoxic T lymphocytes and CD4 epitope mutations in the pre-core/core region of hepatitis B virus in chronic hepatitis B carriers in Northeast Iran.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2017Article
- The correlation between serum HBsAg levels and viral loads depends upon wild-type and mutated HBV sequences rather than the HBeAg/anti-HBe status.Journal of medical virology · 2015Article
- Article
- Correlation between HBsAg quantitation and HBV DNA in HBeAg-negative HBV/D patients.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology AssociationArticle
- SASLT practice guidelines for the management of Hepatitis B virus - An update.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology AssociationArticle
- Correlation between hepatitis B surface antigen titers and HBV DNA levels: what about the parameters affecting this correlation?Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology AssociationArticle
- Quantitative HBsAg levels do not identify hepatic fibrosis in HBeAg-negative chronic hepatitis B patients.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology AssociationArticle
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8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimTo assess the correlation between serum HBsAg titers and hepatitis B virus (HBV) DNA levels in patients with hepatitis B envelop antigen-negative (HBeAg -ve) HBV genotype-D (HBV/D) infection. PATIENTS AND
methodsA total of 106 treatment- naïve, HBeAg -ve HBV/D patients were included; 78 in the inactive carrier (IC) state and 28 in the active hepatitis (AH) stage. HBV DNA load and HBsAg titers were tested using TaqMan real-time polymerase chain reaction (PCR) and automated chemiluminescent microparticle immunoassay, respectively.
resultsThe median (range) log10 HBsAg titer was significantly lower in the IC group compared with AH group, 3.09 (-1 to -4.4) versus 3.68 (-0.77 to 5.09) IU/mL, respectively; P < 0.001. The suggested cutoff value of HBsAg titer to differentiate between the two groups was 3.79 log10 IU/mL. In addition, there was a significant positive correlation between HBsAg and HBV DNA levels in the whole cohort, AH, and IC groups (r = 0.6, P < 0.0001; r = 0.591, P = 0.001; and r = 0.243, P = 0.032, respectively).
conclusionSerum HBsAg titers may correlate with HBV DNA in treatment-naïve HBeAg -ve HBV/D patients, and supports the use of HBsAg levels in clinical practice as a predictor of serum HBV DNA levels.
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