ArticleMobile DNA2013
A proposed mechanism for IS607-family serine transposases.
Article in Mobile DNA, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 50 citations in OpenAlex.
- The TIGER/Islander resource for genomic islands.Microbiology resource announcements · 2025Article
- Antagonistic conflict between transposon-encoded introns and guide RNAs.Science (New York, N.Y.) · 2024Article
- Discovery and structural mechanism of DNA endonucleases guided by RAGATH-18-derived RNAs.Cell research · 2024Article
- Eukaryotic RNA-guided endonucleases evolved from a unique clade of bacterial enzymes.Nucleic acids research · 2023Article
- Transposon-encoded nucleases use guide RNAs to selfishly bias their inheritance.bioRxiv : the preprint server for biology · 2023Article
- Phylogenetic Relationships among TnpB-Containing Mobile Elements in Six Bacterial Species.Genes · 2023Article
- digIS: towards detecting distant and putative novel insertion sequence elements in prokaryotic genomes.BMC bioinformatics · 2021Article
- New candidates for regulated gene integrity revealed through precise mapping of integrative genetic elements.Nucleic acids research · 2020Article
- ISMobile DNA · 2020Review
- Role of plasmid plasticity and mobile genetic elements in the entomopathogen Bacillus thuringiensis serovar israelensis.FEMS microbiology reviews · 2018Article
- Multiple serine transposase dimers assemble the transposon-end synaptic complex during ISeLife · 2018Article
- Article
- DNA Transposition at Work.Chemical reviews · 2016Review
- Recent Mobility of Casposons, Self-Synthesizing Transposons at the Origin of the CRISPR-Cas Immunity.Genome biology and evolution · 2016Article
- ISC, a Novel Group of Bacterial and Archaeal DNA Transposons That Encode Cas9 Homologs.Journal of bacteriology · 2015Article
- Mechanisms of DNA Transposition.Microbiology spectrum · 2015Review
- Evolution of adaptive immunity from transposable elements combined with innate immune systems.Nature reviews. Genetics · 2015Review
- Site-specific DNA Inversion by Serine Recombinases.Microbiology spectrum · 2015Article
- Survey of chimeric IStron elements in bacterial genomes: multiple molecular symbioses between group I intron ribozymes and DNA transposons.Nucleic acids research · 2014Article
- Bacterial insertion sequences: their genomic impact and diversity.FEMS microbiology reviews · 2014Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundThe transposases encoded by the IS607 family of mobile elements are unusual serine recombinases with an inverted domain order and minimal specificity for target DNA.
resultsStructural genomics groups have determined three crystal structures of the catalytic domains of IS607 family transposases. The dimers formed by these catalytic domains are very different from those seen for other serine recombinases and include interactions that usually only occur upon formation of a synaptic tetramer.
conclusionsBased on these structures, we propose a model for how IS607-family transposases could form a synaptic tetramer. The model suggests that, unlike other serine recombinases, these enzymes carry out sequence-specific DNA binding and catalysis in trans: the DNA binding and catalytic domains of each subunit are proposed to interact with different DNA duplexes. The model also suggests an explanation for the minimal target DNA specificity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.