ArticleAnalytical chemistry2013
Direct quantitative analysis of nicotine alkaloids from biofluid samples using paper spray mass spectrometry.
Article in Analytical chemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 89 citations in OpenAlex.
- Proteomics for Low Cell Numbers: How to Optimize the Sample Preparation Workflow for Mass Spectrometry Analysis.Journal of proteome research · 2021Article
- Paper spray ionization-high-resolution mass spectrometry (PSI-HRMS) of peroxide explosives in biological matrices.Analytical and bioanalytical chemistry · 2021Article
- Accelerated nucleophilic substitution reactions of dansyl chloride with aniline under ambient conditions via dual-tip reactive paper spray.Scientific reports · 2020Article
- Emerging trends in paper spray mass spectrometry: Microsampling, storage, direct analysis, and applications.Mass spectrometry reviews · 2020Review
- Direct Analysis of Doping Agents in Raw Urine Using Hydrophobic Paper Spray Mass Spectrometry.Journal of the American Society for Mass Spectrometry · 2020Article
- Using Sesame Seed Oil to Preserve and Preconcentrate Cannabinoids for Paper Spray Mass Spectrometry.Journal of the American Society for Mass Spectrometry · 2020Article
- A Polymer Coating Transfer Enrichment Method for Direct Mass Spectrometry Analysis of Lipids in Biofluid Samples.Angewandte Chemie (International ed. in English) · 2019Article
- Paper spray ionization mass spectrometry: recent advances and clinical applications.Expert review of proteomics · 2018Review
- Paper Spray Mass Spectrometry for High-Throughput Quantification of Nicotine and Cotinine.Analytical methods : advancing methods and applications · 2018Article
- Paper-based MoSScientific reports · 2017Article
- Ambient Ionization Mass Spectrometry Measurement of Aminotransferase Activity.Journal of the American Society for Mass Spectrometry · 2017Article
- Ambient Ionization and Miniature Mass Spectrometry Systems for Disease Diagnosis and Therapeutic Monitoring.Theranostics · 2017Review
- Ionization Suppression and Recovery in Direct Biofluid Analysis Using Paper Spray Mass Spectrometry.Journal of the American Society for Mass Spectrometry · 2016Article
- Ambient Ionization Mass Spectrometry for Point-of-Care Diagnostics and Other Clinical Measurements.Clinical chemistry · 2016Review
- Development of miniature mass spectrometry systems for bioanalysis outside the conventional laboratories.Bioanalysis · 2014Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
The determination of tobacco derived nicotine alkaloids in biofluid samples is of great importance to testing for tobacco use, tobacco cessation treatment, and studies on exposure to secondhand smoke. Paper spray mass spectrometry (MS) has been adapted for direct, quantitative analysis of tobacco alkaloids from biofluid samples, such as blood, urine, and saliva in liquid and dried form. Limits of quantitation as low as several nanograms per milliliter were obtained for nicotine, cotinine, trans-3'-hydroxycotinine, and anabasine. Direct analysis of fresh blood samples has also been achieved with improved sensitivity using print paper substrates of high density. Quantitation of the cotinine in the blood of a rat was performed with both direct analysis using paper spray and a traditional analysis protocol using liquid chromatography MS. Comparable results were obtained and the precision of the two methods was similar. The paper spray MS method is rapid and shows potential for significantly improved analytical efficiency in clinical laboratories as well as for point-of-care tobacco use assessment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.