ArticleBMC neurology2013
Visual pursuit response in the severe disorder of consciousness: modulation by the central autonomic system and a predictive model.
Article in BMC neurology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Eye movements as indicators of awareness in prolonged disorders of consciousness: a scoping review of behavioral and neural evidence.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Autonomic heart rate variability trends predict outcome in disorders of consciousness.Scientific reports · 2025Article
- Central autonomic network and early prognosis in patients with disorders of consciousness.Scientific reports · 2024Article
- Pain Perception in Disorder of Consciousness: A Scoping Review on Current Knowledge, Clinical Applications, and Future Perspective.Brain sciences · 2021Article
- The Impact of Medical Complications in Predicting the Rehabilitation Outcome of Patients With Disorders of Consciousness After Severe Traumatic Brain Injury.Frontiers in human neuroscience · 2020Article
- Circadian Rhythms and Measures of CNS/Autonomic Interaction.International journal of environmental research and public health · 2019Review
- Outcome prediction in disorders of consciousness: the role of coma recovery scale revised.BMC neurology · 2019Observational
- Measures of CNS-Autonomic Interaction and Responsiveness in Disorder of Consciousness.Frontiers in neuroscience · 2019Review
- A Heartbeat Away From Consciousness: Heart Rate Variability Entropy Can Discriminate Disorders of Consciousness and Is Correlated With Resting-State fMRI Brain Connectivity of the Central Autonomic Network.Frontiers in neurology · 2018Article
- An Auditory BCI System for Assisting CRS-R Behavioral Assessment in Patients with Disorders of Consciousness.Scientific reports · 2016Article
- Pain Perception in Unresponsive Wakefulness Syndrome May Challenge the Interruption of Artificial Nutrition and Hydration: Neuroethics in Action.Frontiers in neurology · 2016Article
- Coma recovery scale-r: variability in the disorder of consciousness.BMC neurology · 2015Article
- Care and neurorehabilitation in the disorder of consciousness: a model in progress.TheScientificWorldJournal · 2015Article
- Autonomic correlates of seeing one's own face in patients with disorders of consciousness.Neuroscience of consciousness · 2015Article
- Responsiveness in DoC and individual variability.Frontiers in human neuroscience · 2015Article
- Assessment of patients with disorder of consciousness: do different Coma Recovery Scale scoring correlate with different settings?Journal of neurology · 2014Article
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4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA visual pursuit response is reportedly observed in ~20-30% of subjects in vegetative state (VS/UWS) and predicts better outcome; it is a key marker of evolution into the minimally conscious state (MCS). The probability of observing a positive response, however, has proven variable during the day, with comparable timing of the minima and maxima in VS/UWS and MCS. We verified if measures of sympathetic/parasympathetic balance are possible independent variables on which the occurrence of a pursuit response could depend and be predicted.
methodsFourteen subjects in VS/UWS and sixteen in MCS for more than one year were studied. A mirror was used to test the pursuit response for a total 231 useful trials. Non-invasive measures of the sympathetic/parasympathetic functional state (Heart rate variability descriptors nuLF and peakLF) used in the study of responsiveness in VS/UWS and MCS subjects were recorded and processed by descriptive statistics and advanced Support Vector Machine (SVM).
resultsA pursuit response was observed in 33% and 78.2% of subjects in VS or MCS, respectively. Incidence was higher at HRV nuLF values in the 20-60 range and peakLF values at 0.06-0.12 Hz (76.6%) and at nuLF values in the 10-60 range and peakLF values at 0.05-0.10 Hz (80.7%) in the VS and MCS, respectively. The SVM generated model confirmed the results in the training leave one out and 10 fold cross validation tests (81% and 81.4%).
conclusionThe pursuit response incidence depends to a relevant extent on the sympathetic/parasympathetic balance and autonomic functional state. Extensive monitoring appears advisable.
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