ArticleInternational journal of ophthalmology2013
Evaluation of corneal graft survival in mice model.
Article in International journal of ophthalmology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Mouse Model of Sutured Endothelial Keratoplasty Technique.Journal of clinical medicine · 2025Article
- Inhibiting corneal transplantation rejection via lymphatic vessel ligation in a novel murine model.Scientific reports · 2024Article
- Myeloid-derived suppressor cells promote allograft survival by suppressing regulatory T cell dysfunction in high-risk corneal transplantation.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2024Article
- Assessment of Corneal Graft Outcomes in a Murine Model of Endothelial Keratoplasty.Journal of clinical medicine · 2024Article
- Pro-inflammatory role of NLRP3 inflammasome in experimental sterile corneal inflammation.Scientific reports · 2019Article
- The Balance of Th1/Th2 and LAP+Tregs/Th17 Cells Is Crucial for Graft Survival in Allogeneic Corneal Transplantation.Journal of ophthalmology · 2018Article
- Optimizing rejection readouts in a corneal allograft transplantation model.Molecular vision · 2016Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the characteristics and criterion of graft rejection in mice model.
methodsC57BL/6 or BALB/c mice corneal grafts were grafted onto BALB/c hosts. Each group was divided into two subgroups according to the corneal opacity scores 12d after transplantation. The characteristics of opacity and neovascularization were observed. Mice of the 12(th), 50(th) day after transplantation, the grafts biopsy of mice in allogeneic group 1, which opacity score exceed 3, were prepared for histological observation and those restore transparent were endothelial stained.
resultsThere was no difference of corneal opacity score on the 7(th) and 12(th) day after operation; the histological results had no disparity between syngeneic group and allogeneic group. On the 12(th) day after surgery, the turbidity curve was apparent in grafts with opacity score < 2. Mononuclear cells were shown in grafts with opacity score reached 3 in allogeneic group 1. Different rejection performance was observed in tissue sections on the 50(th) day after surgery.
conclusionGrafts, opacity score exceeds 3 from the 7(th) to the 12(th) day after operation could not be judged as a rejection. We should pay more attention to the variation of grafts opacity since 12d after corneal transplantation.
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