SynthesisPloS one2013
Periodontal disease and risk of head and neck cancer: a meta-analysis of observational studies.
Synthesis in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers, 22 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
84 citing papers in PubMed, 22 syntheses or guidelines pooled it, 135 citations in OpenAlex.
- Periodontal Disease and Incidence of Cancers: A Systematic Review and Meta-analysis of Cohort Studies.International dental journal · 2026Pooled it
- Risk of cancer in periodontal disease: an umbrella review of meta-analyses.Frontiers in immunology · 2026Pooled it
- Demystifying the link between periodontitis and oral cancer: a systematic review integrating clinical, pre-clinical, and in vitro data.Cancer metastasis reviews · 2025Pooled it
- Preterm birth among Pacific Islanders in the United States and the US-affiliated Pacific Islands: A systematic review and meta-analysis.Birth (Berkeley, Calif.) · 2023Pooled it
- Periodontal disease and Helicobacter pylori infection in oral cavity: a meta-analysis of 2727 participants mainly based on Asian studies.Clinical oral investigations · 2020Pooled it
- Hematopoietic and lymphatic cancers in patients with periodontitis: a systematic review and meta-analysis.Medicina oral, patologia oral y cirugia bucal · 2020Pooled it
- Periodontal Disease and Tooth Loss Are Associated with Lung Cancer Risk.BioMed research international · 2020Pooled it
- Potential risk of certain cancers among patients with Periodontitis: a supplementary meta-analysis of a large-scale population.International journal of medical sciences · 2020Pooled it
- The association between chronic periodontitis and oral Helicobacter pylori: A meta-analysis.PloS one · 2019Pooled it
- Salivary matrix metalloproteinase (MMP)-8 as a biomarker for periodontitis: A PRISMA-compliant systematic review and meta-analysis.Medicine · 2018Pooled it
- Pooled it
- Interleukin-10 rs1800896 polymorphism is associated with increased head and neck cancer risk but not associated with its clinical stages.Oncotarget · 2017Pooled it
- Pooled it
- Periodontal Disease, Tooth Loss, and Cancer Risk.Epidemiologic reviews · 2017Pooled it
- COX-2 rs689466, rs5275, and rs20417 polymorphisms and risk of head and neck squamous cell carcinoma: a meta-analysis of adjusted and unadjusted data.BMC cancer · 2016Pooled it
- Matrix metalloproteinase gene polymorphisms and periodontitis susceptibility: a meta-analysis involving 6,162 individuals.Scientific reports · 2016Pooled it
- Tooth loss is associated with increased risk of esophageal cancer: evidence from a meta-analysis with dose-response analysis.Scientific reports · 2016Pooled it
- Cyclooxygenase-2-1195G>A Polymorphism and Head and Neck Squamous Cell Carcinoma Susceptibility: A Meta-Analysis of 1564 Cases and 2346 Controls.Medical science monitor : international medical journal of experimental and clinical research · 2015Pooled it
- Matrix Metalloproteinase-3 -1171 5A/6A Polymorphism (rs35068180) is Associated with Risk of Periodontitis.Scientific reports · 2015Pooled it
- Association between Estrogen Receptor-α Gene XbaI and PvuII Polymorphisms and Periodontitis Susceptibility: A Meta-Analysis.Disease markers · 2015Pooled it
24 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMany epidemiological studies have found a positive association of periodontal disease (PD) with risk of head and neck cancer (HNC), but the findings are varied or even contradictory. In this work, we performed a meta-analysis to ascertain the relationship between PD and HNC risk.
methodsWe searched the PubMed, Embase, and Cochrane Library databases for relevant observational studies on the association between PD and HNC risk published up to March 23, 2013. Data from the included studies were extracted and analyzed independently by two authors. Meta-analysis was performed using RevMan 5.2 software.
resultsWe obtained seven observational studies involving two cohort and six case-control studies. Random-effects meta-analysis indicated a significant association between PD and HNC risk (odds ratio = 2.63, 95% confidence interval = 1.1.68 - 4.14; p < 0.001), with sensitivity analysis showing that the result was robust. Subgroup analyses based on adjustment for covariates, study design, PD assessment, tumor site, and ethnicity also revealed a significant association.
conclusionsBased on currently evidence, PD is probably a significant and independent risk factor of HNC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.