ArticlePloS one2013
Population genomic analysis reveals a rich speciation and demographic history of orang-utans (Pongo pygmaeus and Pongo abelii).
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed.
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- Evolutionary consequences of domestication on the selective effects of new amino acid changing mutations in canids.bioRxiv : the preprint server for biology · 2024Article
- Using Computational Simulations to Model Deleterious Variation and Genetic Load in Natural Populations.The American naturalist · 2023Review
- Quantifying the fraction of new mutations that are recessive lethal.Evolution; international journal of organic evolution · 2023Article
- Expanding the stdpopsim species catalog, and lessons learned for realistic genome simulations.eLife · 2023Article
- Models based on best-available information support a low inbreeding load and potential for recovery in the vaquita.Heredity · 2023Article
- Nine out of ten samples were mistakenly switched by The Orang-utan Genome Consortium.Scientific data · 2022Article
- On the prospect of achieving accurate joint estimation of selection with population history.Genome biology and evolution · 2022Article
- Inferring Genome-Wide Correlations of Mutation Fitness Effects between Populations.Molecular biology and evolution · 2021Article
- Short Tandem Repeats as a High-Resolution Marker for Capturing Recent Orangutan Population Evolution.Frontiers in bioinformatics · 2021Article
- Adaptation, ancestral variation and gene flow in a 'Sky Island' Drosophila species.Molecular ecology · 2021Article
- Two to Tango: Co-evolution of Hominid Natural Killer Cell Receptors and MHC.Frontiers in immunology · 2019Review
- ABLE: blockwise site frequency spectra for inferring complex population histories and recombination.Genome biology · 2018Article
- Inference of the Distribution of Selection Coefficients for New Nonsynonymous Mutations Using Large Samples.Genetics · 2017Article
- The Y chromosomes of the great apes.Human genetics · 2017Review
- Two Orangutan Species Have Evolved DifferentJournal of immunology (Baltimore, Md. : 1950) · 2017Article
- Accelerated diversification of nonhuman primate malarias in Southeast Asia: adaptive radiation or geographic speciation?Molecular biology and evolution · 2015Article
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11 authors.
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Abstract
To gain insights into evolutionary forces that have shaped the history of Bornean and Sumatran populations of orang-utans, we compare patterns of variation across more than 11 million single nucleotide polymorphisms found by previous mitochondrial and autosomal genome sequencing of 10 wild-caught orang-utans. Our analysis of the mitochondrial data yields a far more ancient split time between the two populations (~3.4 million years ago) than estimates based on autosomal data (0.4 million years ago), suggesting a complex speciation process with moderate levels of primarily male migration. We find that the distribution of selection coefficients consistent with the observed frequency spectrum of autosomal non-synonymous polymorphisms in orang-utans is similar to the distribution in humans. Our analysis indicates that 35% of genes have evolved under detectable negative selection. Overall, our findings suggest that purifying natural selection, genetic drift, and a complex demographic history are the dominant drivers of genome evolution for the two orang-utan populations.
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