ArticlePloS one2013
Dynamic response of model lipid membranes to ultrasonic radiation force.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
47 citing papers in PubMed, 89 citations in OpenAlex.
- Precisely Engineering Biomimetic Nanoparticles via Controlled Cell Membrane Coating.Small (Weinheim an der Bergstrasse, Germany) · 2026Review
- Transcranial focused ultrasound modulates spiking, LFP, and BOLD activity in the primate thalamus.Nature communications · 2026Article
- Experimental evaluation of an integrated focused ultrasound and electroencephalography approach for developing activation-informed neuroimaging.NeuroImage · 2026Article
- A Multi-Channel AM-TMAS Driving System Based on Amplitude-Modulated Sine Waves.Bioengineering (Basel, Switzerland) · 2026Article
- Surface acoustic wave hemolysis assay for evaluating stored red blood cells.Lab on a chip · 2026Article
- Individualized non-invasive deep brain stimulation of the basal ganglia using transcranial ultrasound stimulation.Nature communications · 2025Article
- Can Neuromodulation Improve Sleep and Psychiatric Symptoms?Current psychiatry reports · 2024Review
- Focal Volume, Acoustic Radiation Force, and Strain in Two-Transducer Regimes.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2024Article
- Article
- Tension activation of mechanosensitive two-pore domain K+ channels TRAAK, TREK-1, and TREK-2.Nature communications · 2024Article
- Therapeutic ultrasound: an innovative approach for targeting neurological disorders affecting the basal ganglia.Frontiers in neuroanatomy · 2024Review
- Principles and applications of sono-optogenetics.Advanced drug delivery reviews · 2023Review
- Ultrasound promotes germination of aging Pinus tabuliformis seeds is associated with altered lipid metabolism.Ultrasonics sonochemistry · 2023Article
- Pressure and ultrasound activate mechanosensitive TRAAK KbioRxiv : the preprint server for biology · 2023Article
- Article
- A tool for monitoring cell type-specific focused ultrasound neuromodulation and control of chronic epilepsy.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Optically-generated focused ultrasound for noninvasive brain stimulation with ultrahigh precision.Light, science & applications · 2022Article
- Focused ultrasound stimulation of an ex-vivo Aplysia abdominal ganglion preparation.Journal of neuroscience methods · 2022Article
- Focused Ultrasound Stimulation as a Neuromodulatory Tool for Parkinson's Disease: A Scoping Review.Brain sciences · 2022Article
- A review of the bioeffects of low-intensity focused ultrasound and the benefits of a cellular approach.Frontiers in physiology · 2022Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Low-intensity ultrasound can modulate action potential firing in neurons in vitro and in vivo. It has been suggested that this effect is mediated by mechanical interactions of ultrasound with neural cell membranes. We investigated whether these proposed interactions could be reproduced for further study in a synthetic lipid bilayer system. We measured the response of protein-free model membranes to low-intensity ultrasound using electrophysiology and laser Doppler vibrometry. We find that ultrasonic radiation force causes oscillation and displacement of lipid membranes, resulting in small (<1%) changes in membrane area and capacitance. Under voltage-clamp, the changes in capacitance manifest as capacitive currents with an exponentially decaying sinusoidal time course. The membrane oscillation can be modeled as a fluid dynamic response to a step change in pressure caused by ultrasonic radiation force, which disrupts the balance of forces between bilayer tension and hydrostatic pressure. We also investigated the origin of the radiation force acting on the bilayer. Part of the radiation force results from the reflection of the ultrasound from the solution/air interface above the bilayer (an effect that is specific to our experimental configuration) but part appears to reflect a direct interaction of ultrasound with the bilayer, related to either acoustic streaming or scattering of sound by the bilayer. Based on these results, we conclude that synthetic lipid bilayers can be used to study the effects of ultrasound on cell membranes and membrane proteins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.