SynthesisPloS one2013
Validity of sealant retention as surrogate for caries prevention--a systematic review.
Synthesis in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- Evaluation of the effectiveness of prophylactic sealing of pits and fissures of permanent teeth with fissure sealants - umbrella review.BMC oral health · 2023Pooled it
- Sealants for preventing dental caries in primary teeth.The Cochrane database of systematic reviews · 2022Pooled it
- Infiltration and sealing for managing non-cavitated proximal lesions: a systematic review and meta-analysis.BMC oral health · 2021Pooled it
- Flowable composite as fissure sealing material? A systematic review and meta-analysis.British dental journal · 2018Pooled it
- Pit and fissure sealants for preventing dental decay in permanent teeth.The Cochrane database of systematic reviews · 2017Pooled it
- Micro-invasive interventions for managing proximal dental decay in primary and permanent teeth.The Cochrane database of systematic reviews · 2015Pooled it
- Validity of sealant retention as surrogate for caries prevention--a systematic review.PloS one · 2013Pooled it
- Clinical Performance of Bioglass-Enriched Resin Modified Glass Ionomer in Sealing Moderate Carious Lesions: An 18-Month Split-Mouth Clinical Trial.International journal of dental hygiene · 2026Trial
- 24-month efficacy of bioactive versus fluoride sealant for non-cavitated occlusal caries in adults: a randomized clinical trial.Scientific reports · 2025Trial
- Comparing the effectiveness of caries arrest by micro-operative treatment to operative treatment: A 2-year randomized controlled clinical trial.Clinical oral investigations · 2024Trial
- Retention rates and caries-preventive effects of two different sealant materials: a randomised clinical trial.Clinical oral investigations · 2018Trial
- Frequency of remnants of sealants left behind in pits and fissures of occlusal surfaces after 2 and 3 years.Clinical oral investigations · 2017Trial
- Micro-CT Assessment of Heat and Vibration Effect on Sealant Penetration in Different Fissure Types.Oral health & preventive dentistry · 2025Article
- Exploring Recent Decreases in First Molar Sealants among US Children.Journal of dental research · 2024Article
- Methods of Primary Clinical Prevention of Dental Caries in the Adult Patient: An Integrative Review.Healthcare (Basel, Switzerland) · 2023Review
- Article
- Comparative Assessment of Retention and Caries Protective Effectiveness of a Hydrophilic and a Conventional Sealant-A Clinical Trial.Children (Basel, Switzerland) · 2022Article
- An Efficacy Study between High Viscosity Glass Ionomers and Resin Sealants in Fissure Caries Prevention: A 2-Year Split Mouth Randomized Controlled Trial.European journal of dentistry · 2022Article
- When to intervene in the caries process? A Delphi consensus statement.British dental journal · 2020Article
- Indirect evaluation of pit and fissure sealants: A 3D-based method validation.Journal of clinical and experimental dentistry · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
INTRODUCTION/
aimTo appraise the clinical literature in determining whether loss of complete sealant retention as surrogate endpoint is directly associated with caries occurrence on sealed teeth as its clinical endpoint and to apply the appraised evidence in testing the null-hypothesis that the retention/caries ratio between different types of sealant materials (resin and glass-ionomer cement) is not statistically significant (= Prentice criterion for surrogate endpoint validity).
methodsDatabases searched PubMed/Medline, Directory of Open Access Journals; IndMed, Scielo. Systematic reviews were checked for suitable trials. The search terms: "fiss* AND seal*" and "fissure AND sealant" were used. Article selection criteria were: clinical trial reporting on the retention and caries occurrence of resin and/or glass-ionomer cement (GIC) fissure sealed permanent molar teeth; minimum 24-month follow-up period; systematic review or meta-analysis. Datasets and information were extracted from accepted trials. The principle outcome measure was the ratio of Risk of loss of complete retention to the Risk of caries occurrence per sealant type (RCR). Risk of bias was assessed in trials and sensitivity analysis with regard to potential confounding factors conducted. The null-hypothesis was tested by graphical and statistical methods.
resultsThe risk of loss of complete retention of sealant materials was associated with the risk of caries occurrence for resin but not for GIC based sealants. The difference between RCR values of the two sealant types was statistically significant (p<0.05). The null-hypothesis was rejected.
conclusionsThe current clinical evidence suggests that complete retention of pit and fissure sealants may not be a valid surrogate endpoint for caries prevention as its clinical endpoint. Further research is required to corroborate the current results.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.