ArticleThe Open bone journal2012
The Important Role of Osteoblasts and Citrate Production in Bone Formation: "Osteoblast Citration" as a New Concept for an Old Relationship.
Article in The Open bone journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed, 112 citations in OpenAlex.
- Effect of Hemodialysis With Citrate on Vascular Calcification.Kidney international reports · 2026Article
- Article
- Spatial transcriptomics for gene discovery identifiesbioRxiv : the preprint server for biology · 2026Article
- Understanding the Role of MicroRNAs in Congenital Tooth Agenesis: A Multi-omics Integration.Biochemical genetics · 2026Article
- Citrate Transporter Expression and Localization: TheInternational journal of molecular sciences · 2025Article
- Metabolomic profiling and 16 S rRNA metabarcoding of endophytes of two Aloe species revealed diverse metabolites.AMB Express · 2024Article
- Metabolic reprogramming in skeletal cell differentiation.Bone research · 2024Review
- Citric Acid: A Nexus Between Cellular Mechanisms and Biomaterial Innovations.Advanced materials (Deerfield Beach, Fla.) · 2024Review
- Effect of Acetylsalicylic Acid on Biological Properties of Novel Cement Based on Calcium Phosphate Doped with Ions of Strontium, Copper, and Zinc.International journal of molecular sciences · 2024Article
- Acidic Osteoid Templates the Plywood Structure of Bone Tissue.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- ROS/MMP-9 mediated CS degradation in BMSC inhibits citric acid metabolism participating in the dual regulation of bone remodelling.Cell death discovery · 2024Article
- Citrate: a key signalling molecule and therapeutic target for bone remodeling disorder.Frontiers in endocrinology · 2024Review
- Targeting Longevity GeneMetabolites · 2023Article
- Panthenol Citrate Biomaterials Accelerate Wound Healing and Restore Tissue Integrity.Advanced healthcare materials · 2023Article
- From Metabolism to Vitality: Uncovering Riboflavin's Importance in Poultry Nutrition.Animals : an open access journal from MDPI · 2023Review
- Sword Bean (Nutrients · 2023Article
- Amorphous Calcium Phosphate and Amorphous Calcium Phosphate Carboxylate: Synthesis and Characterization.ACS omega · 2023Article
- Mapping the Metabolic Niche of Citrate Metabolism andMetabolites · 2023Review
- Role of carboxylic organic molecules in interfibrillar collagen mineralization.Frontiers in bioengineering and biotechnology · 2023Review
- Preclinical and Clinical Evidence of Effect of Acid on Bone Health.Advances in chronic kidney disease · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
It has been known for about seventy years that bone, in all vertebrates, contains uniquely high citrate levels. However, the role of citrate, its source, its regulation, and its implication in normal bone formation and in bone disorders have remained largely unknown. For the past thirty-five years, the relationship of citrate in bone has been a neglected area of attention and research. It has recently been discovered that citrate is critical for the structure of the apatite nanocrystal, and is required to impart the important properties of bone such as its stability, strength, and resistance to fracture. This brings to focus the need for a renewed interest and research into the relationships of citrate in bone formation. A most fundamental question that must be resolved is "What is the source of citrate in bone?". This presentation provides a historical review of the early research to the present status of citrate implications in bone. This leads to a new concept of the role of osteoblasts as specialized citrate producing cells that provide the source of citrate in bone formation; i.e. the "osteoblast citration" process. This also brings into focus a new insight into the role of zinc in bone in relation to osteoblast citrate production. The genetic/hormonal/metabolic relationships of "net citrate production" are described. The intent of this presentation is to provide the background for a new perspective of the important implications of osteoblasts and citrate in bone formation; which, hopefully, will stimulate a renewed interest and essential research.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.