ArticleEvidence-based complementary and alternative medicine : eCAM2013
Ginseng extracts restore high-glucose induced vascular dysfunctions by altering triglyceride metabolism and downregulation of atherosclerosis-related genes.
Article in Evidence-based complementary and alternative medicine : eCAM, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 16 citations in OpenAlex.
- Mechanistic elucidation ofJournal of ginseng research · 2026Article
- Possibility as role of ginseng and ginsenosides on inhibiting the heart disease of COVID-19: A systematic review.Journal of ginseng research · 2022Review
- Feeding foliar nano-selenium biofortified panax notoginseng could reduce the occurrence of glycolipid metabolism disorder in mice caused by high-fat diets.Frontiers in nutrition · 2022Article
- Curcumin as a Natural Remedy for Atherosclerosis: A Pharmacological Review.Molecules (Basel, Switzerland) · 2021Review
- Ginsenoside Rb1 Ameliorates Diabetic Arterial StiffeningFrontiers in pharmacology · 2021Article
- Network Pharmacology Databases for Traditional Chinese Medicine: Review and Assessment.Frontiers in pharmacology · 2019Review
- Alleviation of diabetic complications by ginsenoside Rg3-enriched red ginseng extract in western diet-fed LDLJournal of ginseng research · 2018Article
- Effects of Ginseng Supplementation and Endurance-Exercise in the Artery-Specific Vascular Responsiveness of Diabetic and Sedentary Rats.Frontiers in physiology · 2018Article
- Article
- TCM-Mesh: The database and analytical system for network pharmacology analysis for TCM preparations.Scientific reports · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The king of herbs, Panax ginseng, has been used widely as a therapeutic agent vis-à-vis its active pharmacological and physiological effects. Based on Chinese pharmacopeia Ben Cao Gang Mu and various pieces of literature, Panax ginseng was believed to exert active vascular protective effects through its antiobesity and anti-inflammation properties. We investigated the vascular protective effects of ginseng by administrating ginseng extracts to rats after the induction of diabetes. We found that Panax ginseng can restore diabetes-induced impaired vasorelaxation and can reduce serum triglyceride but not cholesterol level in the diabetic rats. The ginseng extracts also suppressed the expression of atherosclerosis-related genes and altered the expression of lipid-related genes. The results provide evidence that Panax ginseng improves vascular dysfunction induced by diabetes and the protective effects may possibly be due to the downregulation of atherosclerosis-related genes and altered lipid metabolism, which help to restore normal endothelium functions.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.