ArticleFrontiers in aging neuroscience2013
Adult age-dependent differences in resting-state connectivity within and between visual-attention and sensorimotor networks.
Article in Frontiers in aging neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.
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Who cites it
37 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Oscillatory dynamics of motor learning across adulthood life span: a systematic review.Frontiers in aging neuroscience · 2025Pooled it
- The older adult brain is less modular, more integrated, and less efficient at rest: A systematic review of large-scale resting-state functional brain networks in aging.Psychophysiology · 2023Pooled it
- Aging, brain network connectivity, and cognition: evidence from resting-state dynamic arterial spin labeling.NeuroImage · 2026Article
- An Imaging-Guided Neural Model Explains Lexical Stress Alteration in Acquired Apraxia of Speech.Human brain mapping · 2025Article
- Protective role of parenthood on age-related brain function in mid- to late-life.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Relationships of functional connectivity of motor cortex, primary somatosensory cortex, and cerebellum to balance performance in middle-aged and older adults.Neurobiology of aging · 2025Article
- Age- and Sex-Specific Patterns in Adult Brain Network Segregation.Human brain mapping · 2025Article
- Age-related differences in resting-state, task-related, and structural brain connectivity: graph theoretical analyses and visual search performance.Brain structure & function · 2024Article
- Alcohol attention bias modulates neural engagement during moral processing.Social neuroscience · 2024Article
- A gradient of hemisphere-specific dorsal to ventral processing routes in parieto-premotor networks.Network neuroscience (Cambridge, Mass.) · 2024Article
- Resting State Networks Related to the Maintenance of Good Cognitive Performance During Healthy Aging.Frontiers in human neuroscience · 2021Article
- Age-Related Decline of Sensorimotor Integration Influences Resting-State Functional Brain Connectivity.Brain sciences · 2020Article
- Age differences in predicting working memory performance from network-based functional connectivity.Cortex; a journal devoted to the study of the nervous system and behavior · 2020Article
- Affect in the Aging Brain: A Neuroimaging Meta-Analysis of Older Vs. Younger Adult Affective Experience and Perception.Affective science · 2020Article
- Alterations of local functional connectivity in lifespan: A resting-state fMRI study.Brain and behavior · 2020Article
- Stronger Functional Connectivity in the Default Mode and Salience Networks Is Associated With Youthful Memory in Superaging.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Age Differences in Vestibular Brain Connectivity Are Associated With Balance Performance.Frontiers in aging neuroscience · 2020Article
- Impaired motor skills and atypical functional connectivity of the sensorimotor system in 40- to 65-year-old adults with autism spectrum disorders.Neurobiology of aging · 2020Article
- Functional Characterization of Atrophy Patterns Related to Cognitive Impairment.Frontiers in neurology · 2020Article
- Dissociable Effects of Aging on Salience Subnetwork Connectivity Mediate Age-Related Changes in Executive Function and Affect.Frontiers in aging neuroscience · 2018Article
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8 authors.
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Abstract
Healthy aging is accompanied by structural and functional changes in the brain, among which a loss of neural specificity (i.e., dedifferentiation) is one of the most consistent findings. Little is known, however, about changes in interregional integration underlying a dedifferentiation across different functional systems. In a large sample (n = 399) of healthy adults aged from 18 to 85 years, we analyzed age-dependent differences in resting-state (RS) (task-independent) functional connectivity (FC) of a set of brain regions derived from a previous fMRI study. In that study, these regions had shown an age-related loss of activation specificity in visual-attention (superior parietal area 7A and dorsal premotor cortex) or sensorimotor (area OP4 of the parietal operculum) tasks. In addition to these dedifferentiated regions, the FC analysis of the present study included "task-general" regions associated with both attention and sensorimotor systems (rostral supplementary motor area and bilateral anterior insula) as defined via meta-analytical co-activation mapping. Within this network, we observed both selective increases and decreases in RS-FC with age. In line with regional activation changes reported previously, we found diminished anti-correlated FC for inter-system connections (i.e., between sensorimotor-related and visual attention-related regions). Our analysis also revealed reduced FC between system-specific and task-general regions, which might reflect age-related deficits in top-down control possibly leading to dedifferentiation of task-specific brain activity. Together, our results underpin the notion that RS-FC changes concur with regional activity changes in the healthy aging brain, presumably contributing jointly to age-related behavioral changes.
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