ArticleFrontiers in neural circuits2013
High concentrations of divalent cations isolate monosynaptic inputs from local circuits in the auditory midbrain.
Article in Frontiers in neural circuits, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Identifying neuron types and circuit mechanisms in the auditory midbrain.Hearing research · 2024Review
- High calcium concentrations reduce cellular excitability of mouse MNTB neurons.Brain research · 2023Article
- Neurotransmitter phenotype and axonal projection patterns of VIP-expressing neurons in the inferior colliculus.Journal of chemical neuroanatomy · 2022Article
- Long-Duration Sound-Induced Facilitation Changes Population Activity in the Inferior Colliculus.Frontiers in systems neuroscience · 2022Article
- Dynamics of the Auditory Continuity Illusion.Frontiers in computational neuroscience · 2021Article
- Synaptic Zinc Enhances Inhibition Mediated by Somatostatin, but not Parvalbumin, Cells in Mouse Auditory Cortex.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Long-range Channelrhodopsin-assisted Circuit Mapping of Inferior Colliculus Neurons with Blue and Red-shifted Channelrhodopsins.Journal of visualized experiments : JoVE · 2020Article
- Subtypes of GABAergic cells in the inferior colliculus.Hearing research · 2019Review
- Rebound from Inhibition: Self-Correction against Neurodegeneration?Journal of clinical & cellular immunology · 2017Article
- L-type calcium channels refine the neural population code of sound level.Journal of neurophysiology · 2016Article
- Local and commissural IC neurons make axosomatic inputs on large GABAergic tectothalamic neurons.The Journal of comparative neurology · 2014Article
- Response features across the auditory midbrain reveal an organization consistent with a dual lemniscal pathway.Journal of neurophysiology · 2014Article
- Postinhibitory rebound neurons and networks are disrupted in retrovirus-induced spongiform neurodegeneration.Journal of neurophysiology · 2014Article
- Midbrain local circuits shape sound intensity codes.Frontiers in neural circuits · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Hierarchical processing of sensory information occurs at multiple levels between the peripheral and central pathway. Different extents of convergence and divergence in top down and bottom up projections makes it difficult to separate the various components activated by a sensory input. In particular, hierarchical processing at sub-cortical levels is little understood. Here we have developed a method to isolate extrinsic inputs to the inferior colliculus (IC), a nucleus in the midbrain region of the auditory system, with extensive ascending and descending convergence. By applying a high concentration of divalent cations (HiDi) locally within the IC, we isolate a HiDi-sensitive from a HiDi-insensitive component of responses evoked by afferent input in brain slices and in vivo during a sound stimulus. Our results suggest that the HiDi-sensitive component is a monosynaptic input to the IC, while the HiDi-insensitive component is a local polysynaptic circuit. Monosynaptic inputs have short latencies, rapid rise times, and underlie first spike latencies. Local inputs have variable delays and evoke long-lasting excitation. In vivo, local circuits have variable onset times and temporal profiles. Our results suggest that high concentrations of divalent cations should prove to be a widely useful method of isolating extrinsic monosynaptic inputs from local circuits in vivo.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.