ArticleNucleic acids research2014
dbPSHP: a database of recent positive selection across human populations.
Article in Nucleic acids research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Combined genome-wide association study of facial traits in Europeans increases explained variance and improves prediction.Nature communications · 2025Article
- PopTradeOff: A database for exploring population-specificity of adaptive evolution, disease susceptibility, and drug responsiveness.Computational and structural biotechnology journal · 2023Article
- VannoPortal: multiscale functional annotation of human genetic variants for interrogating molecular mechanism of traits and diseases.Nucleic acids research · 2022Article
- Article
- No Evidence for Widespread Positive Selection Signatures in Common Risk Alleles Associated with Schizophrenia.Schizophrenia bulletin · 2020Article
- Regions of homozygosity as risk factors for multiple myeloma.Annals of human genetics · 2019Article
- PopHumanScan: the online catalog of human genome adaptation.Nucleic acids research · 2019Article
- Pseudogenes Provide Evolutionary Evidence for the Competitive Endogenous RNA Hypothesis.Molecular biology and evolution · 2018Article
- Cohort-wide deep whole genome sequencing and the allelic architecture of complex traits.Nature communications · 2018Article
- High-throughput inference of pairwise coalescence times identifies signals of selection and enriched disease heritability.Nature genetics · 2018Article
- DNA Methylation variability among individuals is related to CpGs cluster density and evolutionary signatures.BMC genomics · 2018Article
- Identification and characterization of two functional variants in the human longevity gene FOXO3.Nature communications · 2017Article
- Soft Sweeps Are the Dominant Mode of Adaptation in the Human Genome.Molecular biology and evolution · 2017Article
- Ancestors' dietary patterns and environments could drive positive selection in genes involved in micronutrient metabolism-the case of cofactor transporters.Genes & nutrition · 2017Article
- Genome-Wide Identification of Regulatory Sequences Undergoing Accelerated Evolution in the Human Genome.Molecular biology and evolution · 2016Article
- GWASdb v2: an update database for human genetic variants identified by genome-wide association studies.Nucleic acids research · 2016Article
- A Molecular Evolutionary Reference for the Human Variome.Molecular biology and evolution · 2016Article
- Genome-wide homozygosity signature and risk of Hodgkin lymphoma.Scientific reports · 2015Article
- Host genetic variation impacts microbiome composition across human body sites.Genome biology · 2015Article
- Allelic Spectra of Risk SNPs Are Different for Environment/Lifestyle Dependent versus Independent Diseases.PLoS genetics · 2015Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The dbPSHP database (http://jjwanglab.org/dbpshp) aims to help researchers to efficiently identify, validate and visualize putative positively selected loci in human evolution and further discover the mechanism governing these natural selections. Recent evolution of human populations at the genomic level reflects the adaptations to the living environments, including climate change and availability and stability of nutrients. Many genetic regions under positive selection have been identified, which assist us to understand how natural selection has shaped population differences. Here, we manually collect recent positive selections in different human populations, consisting of 15,472 loci from 132 publications. We further compiled a database that used 15 statistical terms of different evolutionary attributes for single nucleotide variant sites from the HapMap 3 and 1000 Genomes Project to identify putative regions under positive selection. These attributes include variant allele/genotype properties, variant heterozygosity, within population diversity, long-range haplotypes, pairwise population differentiation and evolutionary conservation. We also provide interactive pages for visualization and annotation of different selective signals. The database is freely available to the public and will be frequently updated.
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