ArticleNucleic acids research2014
SelenoDB 2.0: annotation of selenoprotein genes in animals and their genetic diversity in humans.
Article in Nucleic acids research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 45 citations in OpenAlex.
- BSepDB: a database of bacterial selenoprotein genes and proteins.BMC genomics · 2026Article
- Overcoming the widespread flaws in the annotation of vertebrate selenoprotein genes in public databases.PLoS computational biology · 2026Article
- 3S-DB identifies an RNA repository facilitating stop codon readthrough for selenocysteine insertion and selenoproteome expansion.Redox biology · 2025Article
- New Perspectives on Selenium and Selenoproteins in Cardiomyopathy.Indian journal of clinical biochemistry : IJCB · 2024Article
- Ancient Loss of Catalytic Selenocysteine Spurred Convergent Adaptation in a Mammalian Oxidoreductase.Genome biology and evolution · 2024Article
- Selenoprotein I (selenoi) as a critical enzyme in the central nervous system.Archives of biochemistry and biophysics · 2022Article
- Bioinformatics of Selenoproteins.Antioxidants & redox signaling · 2020Review
- Bioinformatics of Metalloproteins and Metalloproteomes.Molecules (Basel, Switzerland) · 2020Review
- RefSeq curation and annotation of stop codon recoding in vertebrates.Nucleic acids research · 2019Article
- Selenium at the redox interface of the genome, metabolome and exposome.Free radical biology & medicine · 2018Review
- Genetic Code Expansion in Animals.ACS chemical biology · 2018Review
- Article
- Selenoprotein K and protein palmitoylation.Antioxidants & redox signaling · 2015Review
- Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 3 countries.
Funding
Abstract
SelenoDB (http://www.selenodb.org) aims to provide high-quality annotations of selenoprotein genes, proteins and SECIS elements. Selenoproteins are proteins that contain the amino acid selenocysteine (Sec) and the first release of the database included annotations for eight species. Since the release of SelenoDB 1.0 many new animal genomes have been sequenced. The annotations of selenoproteins in new genomes usually contain many errors in major databases. For this reason, we have now fully annotated selenoprotein genes in 58 animal genomes. We provide manually curated annotations for human selenoproteins, whereas we use an automatic annotation pipeline to annotate selenoprotein genes in other animal genomes. In addition, we annotate the homologous genes containing cysteine (Cys) instead of Sec. Finally, we have surveyed genetic variation in the annotated genes in humans. We use exon capture and resequencing approaches to identify single-nucleotide polymorphisms in more than 50 human populations around the world. We thus present a detailed view of the genetic divergence of Sec- and Cys-containing genes in animals and their diversity in humans. The addition of these datasets into the second release of the database provides a valuable resource for addressing medical and evolutionary questions in selenium biology.
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Registered trials
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