ArticleJournal of applied toxicology : JAT2014
Calcium montmorillonite clay reduces AFB1 and FB1 biomarkers in rats exposed to single and co-exposures of aflatoxin and fumonisin.
Article in Journal of applied toxicology : JAT, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 49 citations in OpenAlex.
- Mitigation of Fumonisin Biomarkers by Green Tea Polyphenols in a High-Risk Population of Hepatocellular Carcinoma.Scientific reports · 2015Trial
- Article
- Aflatoxin Exposure-Caused Male Reproductive Toxicity: Molecular Mechanisms, Detoxification, and Future Directions.Biomolecules · 2024Review
- Seed Priming with RhizosphericToxins · 2024Article
- Thermogravimetric Analysis of Moisture in Natural and Thermally Treated Clay Materials.Materials (Basel, Switzerland) · 2024Article
- Immunomodulatory effects of aflatoxin B1 (AFB1) and the use of natural products to ameliorate its immunotoxic effects: A review.Open research Africa · 2023Review
- Machine learning-aided design of composite mycotoxin detoxifier material for animal feed.Scientific reports · 2022Article
- Fumonisin B1 Accumulates in Chicken Tissues over Time and This Accumulation Was Reduced by Feeding Algo-Clay.Toxins · 2021Article
- Article
- Tight sorption of arsenic, cadmium, mercury, and lead by edible activated carbon and acid-processed montmorillonite clay.Environmental science and pollution research international · 2021Article
- Potential Applications of Clay-Based Therapy for the Reduction of Pesticide Exposures in Humans and Animals.Applied sciences (Basel, Switzerland) · 2019Article
- Article
- Review
- Article
- NovaSil clay for the protection of humans and animals from aflatoxins and other contaminants.Clays and clay minerals · 2019Article
- Development of broad-acting clays for the tight adsorption of benzo[a]pyrene and aldicarb.Applied clay science · 2019Article
- Development of enterosorbents that can be added to food and water to reduce toxin exposures during disasters.Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes · 2019Article
- Development of High Capacity Enterosorbents for Aflatoxin B1 and Other Hazardous Chemicals.Chemical research in toxicology · 2017Article
- Biologically Based Methods for Control of Fumonisin-Producing Fusarium Species and Reduction of the Fumonisins.Frontiers in microbiology · 2016Review
- Prevalence and effects of mycotoxins on poultry health and performance, and recent development in mycotoxin counteracting strategies.Poultry science · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 4 institutions in 3 countries.
Funding
Abstract
Aflatoxins (AFs) and fumonisins (FBs) can co-contaminate foodstuffs and have been associated with hepatocellular and esophageal carcinomas in humans at high risk for exposure. One strategy to reduce exposure (and toxicity) from contaminated foodstuffs is the dietary inclusion of a montmorillonite clay (UPSN) that binds AFs and FBs in the gastrointestinal tract. In this study, the binding capacity of UPSN was evaluated for AFB1, FB1 and a combination thereof in Fischer 344 rats. Rats were pre-treated with different dietary levels of UPSN (0.25% or 2%) for 1 week. Rats were gavaged with a single dose of either 0.125 mg AFB1 or 25 mg FB1 per kg body weight and a combination thereof in the presence and absence of an aqueous solution of UPSN. The kinetics of mycotoxin excretion were monitored by analyzing serum AFB1 -albumin, urinary AF (AFM1) and FB1 biomarkers over a period of 72 h. UPSN decreased AFM1 excretion by 88-97%, indicating highly effective binding. FB1 excretion was reduced, to a lesser extent, ranging from 45% to 85%. When in combination, both AFB1 and FB1 binding occurred, but capacity was decreased by almost half. In the absence of UPSN, the combined AFB1 and FB1 treatment decreased the urinary biomarkers by 67% and 45% respectively, but increased levels of AFB1 -albumin, presumably by modulating its cytochrome metabolism. UPSN significantly reduced bioavailability of both AFB1 and FB1 when in combination; suggesting that it can be utilized to reduce levels below their respective thresholds for affecting adverse biological effects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.