ArticleTranslational psychiatry2013
Angiotensin-converting enzyme gene variants are associated with both cortisol secretion and late-life depression.
Article in Translational psychiatry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- Genetic Landscape of Major Depressive Disorder: Assessment of Potential Diagnostic and Antidepressant Response Markers.The international journal of neuropsychopharmacology · 2023Pooled it
- Can we clinically recognize a vascular depression? The role of personality in an expanded threshold model.Medicine · 2015Trial
- Predicting depression severity using machine learning models: Insights from mitochondrial peptides and clinical factors.PloS one · 2025Article
- Brain-derived neurotrophic factor (BDNF) variants and promoter I methylation are associated with prolonged nocturnal awakenings in older adults.Journal of sleep research · 2023Article
- Antihypertensive drugs and brain function: mechanisms underlying therapeutically beneficial and harmful neuropsychiatric effects.Cardiovascular research · 2023Review
- Angiotensin I converting enzyme gene polymorphisms and risk of psychiatric disorders.BMC psychiatry · 2022Article
- Association of the angiotensin I converting enzyme (ACE) gene polymorphisms with recurrent aphthous stomatitis in the Czech population: case-control study.BMC oral health · 2022Article
- Renin-angiotensin system: The underlying mechanisms and promising therapeutical target for depression and anxiety.Frontiers in immunology · 2022Review
- Steroid 21-hydroxylase gene variants and late-life depression.BMC research notes · 2021Article
- How Does COVID-19 Affect the Neurobiology of Suicide?Current psychiatry reports · 2021Review
- 11β-Hydroxylase (CYP11B1) gene variants and new-onset depression in later life.Journal of psychiatry & neuroscience : JPN · 2021Article
- Chronically infused angiotensin II induces depressive-like behavior via microglia activation.Scientific reports · 2020Article
- Expression alteration of microRNAs in Nucleus Accumbens is associated with chronic stress and antidepressant treatment in rats.BMC medical informatics and decision making · 2019Article
- Mechanisms and treatment of late-life depression.Translational psychiatry · 2019Review
- Lifetime major depression and grey-matter volumeJournal of psychiatry & neuroscience : JPN · 2019Article
- Aberrant Default Mode Network Underlying the Cognitive Deficits in the Patients With Late-Onset Depression.Frontiers in aging neuroscience · 2018Review
- The effect of an adverse psychological environment on salivary cortisol levels in the elderly differs byNeurobiology of stress · 2017Article
- Investigating the epigenetic profile of the inflammatory gene IL-6 in late-life depression.BMC psychiatry · 2017Article
- The renin-angiotensin system: a possible new target for depression.BMC medicine · 2017Review
- The genetics of anxiety-related negative valence system traits.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2017Review
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Authors and funding
6 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Angiotensin-converting enzyme (ACE) is assumed to influence the activity of the hypothalamic-pituitary-adrenocortical (HPA) axis, which shows hyperactivity in depressed patients. ACE could thus be a promising candidate gene for late-life depression but this has not been examined previously. Depression was assessed in 1005 persons aged at least 65 years, at baseline and over the 10-year follow-up. A clinical level of depression (DEP) was defined as having a score of > or =16 on the Centre for Epidemiology Studies-Depression scale or a diagnosis of current major depression based on the Mini International Neuropsychiatric Interview and according to DSM-IV criteria. Seven single-nucleotide polymorphisms (SNPs) in the ACE gene were genotyped and diurnal cortisol secretion, as an index of HPA axis activity, was measured. Multivariable analyses were adjusted for socio-demographic and vascular factors, cognitive impairment, and apolipoprotein E. Strong significant associations were found between all seven SNPs and DEP and, in particular, first-onset DEP in persons without a past history of depression (P-values ranging from 0.005 to 0.0004). These associations remained significant after correction for multiple testing. The genotypes that were associated with an increased risk of DEP were also significantly associated with an increase in cortisol secretion under stress conditions. Variants of the ACE gene influence cortisol secretion and appear as susceptibility factors for late-life depression in the elderly population. Whether this could represent a common pathophysiological mechanism linking HPA axis and late-life depression remains to be explored.
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