ArticleInternational journal of obesity (2005)2014
Multifactorial analysis of changes in body mass index across the adult life course: a study with 65 years of follow-up.
Article in International journal of obesity (2005), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Obesity, physical activity, and gene-environment interactions: a natural experiment framework.Journal of health, population, and nutrition · 2026Article
- Associations of birth size with BMI trajectories and fluctuation across adolescence and adulthood: A longitudinal study of two Finnish twin cohorts.Early human development · 2025Article
- IGFBP-1 and IGF-I in relation to adiposity and mortality from midlife to old age in the Swedish Adoption/Twin Study of Aging.International journal of obesity (2005) · 2025Article
- Impact of Weight Gain on Cardiovascular Outcomes in Patients With Atrial Fibrillation.Journal of the American Heart Association · 2024Article
- Polygenic risk of obesity and BMI trajectories over 36 years: A longitudinal study of adult Finnish twins.Obesity (Silver Spring, Md.) · 2023Article
- Overweight in Older Adults: A Follow-Up of Fifteen Years of the SABE Survey.International journal of environmental research and public health · 2023Article
- Article
- Determining the stability of genome-wide factors in BMI between ages 40 to 69 years.PLoS genetics · 2022Article
- Differences in Body Mass Index Trajectories and Their Classification, Sociodemographic Characteristics, and Health Behaviors between People with and without Disabilities Using Korea Health Panel Survey Data.International journal of environmental research and public health · 2022Article
- Sex-Specific Patterns of Body Mass Index Relationship with White Matter Connectivity.Journal of Alzheimer's disease : JAD · 2022Article
- Individual changes in anthropometric measures after age 60 years: a 15-year longitudinal population-based study.Age and ageing · 2021Article
- The dynamic association between body mass index and cognition from midlife through late-life, and the effect of sex and genetic influences.Scientific reports · 2021Article
- Change in cognition and body mass index in relation to preclinical dementia.Alzheimer's & dementia (New York, N. Y.) · 2021Article
- Synergistic Effects and Sex Differences in Anthropometric Measures of Obesity and Elevated High-Sensitivity C-Reactive Protein Levels.International journal of environmental research and public health · 2020Article
- Evidence of Bidirectional Associations Between Depressive Symptoms and Body Mass Among Older Adults.The journals of gerontology. Series B, Psychological sciences and social sciences · 2020Article
- Replicating associations between DNA methylation and body mass index in a longitudinal sample of older twins.International journal of obesity (2005) · 2020Article
- Associations between Dietary Inflammatory Index Scores and Inflammatory Biomarkers among Older Adults in the Lothian Birth Cohort 1936 Study.The journal of nutrition, health & aging · 2019Article
- Spirituality/Religiosity (SpR), Leisure-Time Physical Activity, and Sedentary Behaviour in Students at a Catholic University.Journal of religion and health · 2018Article
- Associations between genetic variants associated with body mass index and trajectories of body fatness across the life course: a longitudinal analysis.International journal of epidemiology · 2018Article
- Article
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Authors and funding
5 authors.
Funding
Abstract
backgroundAlthough the negative consequences on health of being obese are well known, most adults gain weight across the lifespan. The general increase in body mass index (BMI) is mainly considered to originate from behavioral and environmental changes; however, few studies have evaluated the influence of these factors on change in BMI in the presence of genetic risk. We aimed to study the influence of multifactorial causes of change in BMI, over 65 years. METHODS AND
findingsTotally, 6130 participants from TwinGene, who had up to five assessments, and 536 from the Swedish Adoption/Twin Study of Aging, who had up to 12 assessments, ranging over 65 years were included. The influence of lifestyle factors, birth cohort, cardiometabolic diseases and an individual obesity genetic risk score (OGRS) based on 32 single nucleotide polymorphisms on change in BMI was evaluated with a growth model. For both sexes, BMI increased from early adulthood to age of 65 years, after which the increase leveled off; BMI declined after age of 80 years. A higher OGRS, birth after 1925 and cardiometabolic diseases were associated with higher average BMI and a steeper increase in BMI prior to 65 years of age. Among men, few factors were identified that influence BMI trajectories in late life, whereas for women type 2 diabetes mellitus and dementia were associated with a steeper decrease in BMI after the age of 65 years.
conclusionsThere are two turning points in BMI in late adulthood, one at the age of 65 years and one at the age 80 years. Factors associated with an increase in BMI in midlife were not associated with an increase in BMI after the age of 65 years. These findings indicate that the causes and consequences of change in BMI differ across the lifespan. Current health recommendations need to be adjusted accordingly.
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