ArticleThe Journal of cell biology1986
Molecular specialization of astrocyte processes at nodes of Ranvier in rat optic nerve.
Article in The Journal of cell biology, 1986. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 161 citations in OpenAlex.
- Functional myelin in cognition and neurodevelopmental disorders.Cellular and molecular life sciences : CMLS · 2024Review
- Role of Extracellular Vesicles in Glia-Neuron Intercellular Communication.Frontiers in molecular neuroscience · 2022Review
- Astrocyte CaScience (New York, N.Y.) · 2021Article
- Neuron-Oligodendrocyte Communication in Myelination of Cortical GABAergic Cells.Life (Basel, Switzerland) · 2021Review
- Mechanisms of node of Ranvier assembly.Nature reviews. Neuroscience · 2021Review
- Nodes of Ranvier during development and repair in the CNS.Nature reviews. Neurology · 2020Review
- Biomaterial strategies for creatingCurrent opinion in biomedical engineering · 2020Article
- Astrocytes Are Required for Oligodendrocyte Survival and Maintenance of Myelin Compaction and Integrity.Frontiers in cellular neuroscience · 2020Article
- Article
- Heterogeneity of astrocyte and NG2 cell insertion at the node of ranvier.The Journal of comparative neurology · 2017Article
- "Targeting astrocytes in CNS injury and disease: A translational research approach".Progress in neurobiology · 2016Review
- Mechanisms of sodium channel clustering and its influence on axonal impulse conduction.Cellular and molecular life sciences : CMLS · 2016Review
- KCNQ2 is a nodal K+ channel.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Genetic dysmyelination alters the molecular architecture of the nodal region.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Autonomic regulation of neuroimmunological responses: implications for multiple sclerosis.Journal of clinical immunology · 2001Review
- Ion channel sequestration in central nervous system axons.The Journal of physiology · 2000Article
- Mice deficient for tenascin-R display alterations of the extracellular matrix and decreased axonal conduction velocities in the CNS.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Ras family GTPases control growth of astrocyte processes.Molecular biology of the cell · 1999Article
- The HNK-1 Carbohydrate Epitope and the Human Eye in Health and Disease.Pathology oncology research : POR · 1997Article
- Morphology of horseradish peroxidase (HRP)-injected glial cells in the myenteric plexus of the guinea-pig.Cell and tissue research · 1994Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The HNK-1 and L2 monoclonal antibodies are thought to recognize identical or closely associated carbohydrate epitopes on a family of neural plasma membrane glycoproteins, including myelin-associated glycoprotein, the neural cell adhesion molecule, and the L1 and J1 glycoproteins, all of which have been postulated to play a part in mediating cell-cell interactions in the nervous system. We have used these two antibodies in immunofluorescence and immunogold-electron microscopic studies of semithin and ultrathin frozen sections of adult rat optic nerve, respectively, and we show that they bind mainly to astrocyte processes around nodes of Ranvier. Most other elements of the nerve, including astrocyte cell bodies and large astrocytic processes, are not labeled by the antibodies. To our knowledge, this is the first demonstration that perinodal astrocyte processes are biochemically specialized. We provide evidence that one of the HNK-1+/L2+ molecules concentrated around perinodal astrocyte processes is the J1 glycoprotein; our findings, taken together with previously reported observations, suggest that the other known HNK-1+/L2+ molecules are not concentrated on these processes. Since anti-J1 antibodies previously have been shown to inhibit neuron to astrocyte adhesion in vitro, we hypothesize that J1 may play an important part in the axon-glial interactions that presumably are involved in the assembly and/or maintenance of nodes of Ranvier.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.