ArticleScientific reports2013
Structure of TCR and antigen complexes at an immunodominant CTL epitope in HIV-1 infection.
Article in Scientific reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 42 citations in OpenAlex.
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- Targeting peptide antigens using a multiallelic MHC I-binding system.Nature biotechnology · 2025Article
- TCR-engineered T cells targeting a shared β-catenin mutation eradicate solid tumors.Nature immunology · 2025Article
- Structural characterization and AlphaFold modeling of human T cell receptor recognition of NRAS cancer neoantigens.Science advances · 2024Article
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- Bw4 ligand and direct T-cell receptor binding induced selection on HLA A and B alleles.Frontiers in immunology · 2023Article
- Stitchr: stitching coding TCR nucleotide sequences from V/J/CDR3 information.Nucleic acids research · 2022Article
- Identification of TCR repertoires in functionally competent cytotoxic T cells cross-reactive to SARS-CoV-2.Communications biology · 2021Article
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- Can Glycosylation Mask the Detection of MHC Expressing p53 Peptides by T Cell Receptors?Biomolecules · 2021Article
- TCR Recognition of Peptide-MHC-I: Rule Makers and Breakers.International journal of molecular sciences · 2020Review
- Structural basis for oligoclonal T cell recognition of a shared p53 cancer neoantigen.Nature communications · 2020Article
- Computational stabilization of T cell receptors allows pairing with antibodies to form bispecifics.Nature communications · 2020Article
- TCRs with Distinct Specificity Profiles Use Different Binding Modes to Engage an Identical Peptide-HLA Complex.Journal of immunology (Baltimore, Md. : 1950) · 2020Article
- Identification of a tumor-specific allo-HLA-restricted γδTCR.Blood advances · 2019Article
- Divergent T-cell receptor recognition modes of a HLA-I restricted extended tumour-associated peptide.Nature communications · 2018Article
- Structural basis for clonal diversity of the human T-cell response to a dominant influenza virus epitope.The Journal of biological chemistry · 2017Article
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Authors and funding
16 authors at 6 institutions in 4 countries.
Funding
Abstract
We investigated the crystal structure of an HLA-A*2402-restricted CTL epitope in the HIV-1 nef gene (Nef134-10) before (pHLA) or after TCR docking. The wild type epitope and two escape mutants were included in the study. Y135F was an early-appearing major mutation, while F139L was a late-appearing mutation which was selected in the patients without Y135F. F139 was an eminent feature of the Nef134-10 epitope. Wild type-specific TCR was less fit to F139L mutant suggesting that F139L is an escape from the CTL against the wild type epitope. Although Y135F mutation disrupted the hydrogen bond to HLA-A*2402 His70, newly formed hydrogen bond between T138 and His70 kept the conformation of the epitope in the reconstituted pMHC. TCR from Y135F- or dually-specific CTL had unique mode of binding to the mutant epitope. Y135F has been reported as a processing mutant but CTL carrying structurally adequate TCR can be found in the patients.
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