ArticleJournal of visualized experiments : JoVE2013
Assessing changes in volatile general anesthetic sensitivity of mice after local or systemic pharmacological intervention.
Article in Journal of visualized experiments : JoVE, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 23 citations in OpenAlex.
- Edinger-Westphal Neurons Contribute to Emergence from Desflurane and Sevoflurane Anesthesia in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Electrophysiological Characterization of Sex-Dependent Hypnosis by an Endogenous Neuroactive Steroid Epipregnanolone.Biomolecules · 2025Article
- Microtubule-modulating drugs alter sensitivity to isoflurane in mice.BMC anesthesiology · 2025Article
- Comparative electrophysiological study of neuroactive steroid-induced hypnosis in mice: sex and drug-specific differences.Experimental biology and medicine (Maywood, N.J.) · 2025Article
- Chronic Neurobehavioral and Neuropathological Consequences of Repeated Blast Exposure in P301S Transgenic Tau Rats.Neurotrauma reports · 2025Article
- Article
- Time to Wake Up! The Ongoing Search for General Anesthetic Reversal Agents.Anesthesiology · 2024Article
- Volatile anaesthetic toxicity in the genetic mitochondrial disease Leigh syndrome.British journal of anaesthesia · 2023Article
- A review of methods used to kill laboratory rodents: issues and opportunities.Laboratory animals · 2022Review
- Historical and Modern Evidence for the Role of Reward Circuitry in Emergence.Anesthesiology · 2022Review
- Pharmacodynamics and Pharmacokinetics of HSK3486, a Novel 2,6-Disubstituted Phenol Derivative as a General Anesthetic.Frontiers in pharmacology · 2022Article
- Comparative effects of dexmedetomidine and propofol on brain and lung damage in experimental acute ischemic stroke.Scientific reports · 2021Article
- Inactivation of Prefrontal Cortex Delays Emergence From Sevoflurane Anesthesia.Frontiers in systems neuroscience · 2021Article
- Return of the Righting Reflex Does Not Portend Recovery of Cognitive Function in Anesthetized Rats.Frontiers in systems neuroscience · 2021Article
- Noninvasive Ultrasound Stimulation of Ventral Tegmental Area Induces Reanimation from General Anaesthesia in Mice.Research (Washington, D.C.) · 2021Article
- Time-lapse 3D Imaging of Phagocytosis by Mouse Macrophages.Journal of visualized experiments : JoVE · 2018Article
- Brainstem Influence on Thalamocortical Oscillations during Anesthesia Emergence.Frontiers in systems neuroscience · 2017Article
- α2-Adrenergic stimulation of the ventrolateral preoptic nucleus destabilizes the anesthetic state.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Sustained increase in α5GABAA receptor function impairs memory after anesthesia.The Journal of clinical investigation · 2014Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
One desirable endpoint of general anesthesia is the state of unconsciousness, also known as hypnosis. Defining the hypnotic state in animals is less straightforward than it is in human patients. A widely used behavioral surrogate for hypnosis in rodents is the loss of righting reflex (LORR), or the point at which the animal no longer responds to their innate instinct to avoid the vulnerability of dorsal recumbency. We have developed a system to assess LORR in 24 mice simultaneously while carefully controlling for potential confounds, including temperature fluctuations and varying gas flows. These chambers permit reliable assessment of anesthetic sensitivity as measured by latency to return of the righting reflex (RORR) following a fixed anesthetic exposure. Alternatively, using stepwise increases (or decreases) in anesthetic concentration, the chambers also enable determination of a population's sensitivity to induction (or emergence) as measured by EC50 and Hill slope. Finally, the controlled environmental chambers described here can be adapted for a variety of alternative uses, including inhaled delivery of other drugs, toxicology studies, and simultaneous real-time monitoring of vital signs.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.