Evidence map›Paper›PMID 24192659›Full record

ReviewJournal of exposure science & environmental epidemiology

Pooled biological specimens for human biomonitoring of environmental chemicals: opportunities and limitations.

Amy L Heffernan, Lesa L Aylward, Leisa-Maree L Toms, Peter D Sly, Matthew Macleod, Jochen F Mueller

Abstract readReview
PubMed Publisher
In one paragraph

Review in Journal of exposure science & environmental epidemiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed.

  1. Article
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  6. Current-use pesticide exposures in remote Inuit communities.International journal of circumpolar health · 2024
    Article
  7. Article
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  13. Generalized additive regression for group testing data.Biostatistics (Oxford, England) · 2021
    Article
  14. Article
  15. Review
  16. Article
  17. Article
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  19. Article
  20. Determination of Varying Group Sizes for Pooling Procedure.Computational and mathematical methods in medicine · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Amy L HeffernanNational Research Centre for Environmental Toxicology (Entox), University of Queensland, Brisbane, Queensland, Australia.
Lesa L AylwardSummit Toxicology, LLP, Falls Church, Virginia, USA.
Leisa-Maree L TomsSchool of Clinical Sciences and Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia.
Peter D SlyChildren's Health and Environment Program, Queensland Children's Medical Research Institute, University of Queensland, Herston, Queensland, Australia.
Matthew MacleodDepartment of Applied Environmental Science, Stockholm University, Stockholm, Sweden.
Jochen F MuellerNational Research Centre for Environmental Toxicology (Entox), University of Queensland, Brisbane, Queensland, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biomonitoring has become the "gold standard" in assessing chemical exposures, and has an important role in risk assessment. The pooling of biological specimens-combining multiple individual specimens into a single sample-can be used in biomonitoring studies to monitor levels of exposure and identify exposure trends or to identify susceptible populations in a cost-effective manner. Pooled samples provide an estimate of central tendency and may also reveal information about variation within the population. The development of a pooling strategy requires careful consideration of the type and number of samples collected, the number of pools required and the number of specimens to combine per pool in order to maximise the type and robustness of the data. Creative pooling strategies can be used to explore exposure-outcome associations, and extrapolation from other larger studies can be useful in identifying elevated exposures in specific individuals. The use of pooled specimens is advantageous as it saves significantly on analytical costs, may reduce the time and resources required for recruitment and, in certain circumstances, allows quantification of samples approaching the limit of detection. In addition, the use of pooled samples can provide population estimates while avoiding ethical difficulties that may be associated with reporting individual results.

Indexed as

Environmental ExposureEnvironmental MonitoringEnvironmental PollutantsHumansEnvironmental Pollutants

Identifiers

PMID24192659

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.