ReviewNutritional neuroscience2014
Damaging effects of a high-fat diet to the brain and cognition: a review of proposed mechanisms.
Review in Nutritional neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 154 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
154 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- History of Sport-Related Concussion and Long-Term Clinical Cognitive Health Outcomes in Retired Athletes: A Systematic Review.Journal of athletic training · 2020Pooled it
- Effects of dietary fat manipulation on cognition in mice and rats: protocol for a systematic review and meta-analysis.BMJ open science · 2020Pooled it
- Fat Consumption Attenuates Cortical Oxygenation during Mental Stress in Young Healthy Adults.Nutrients · 2023Trial
- PQBP1-dependent alternative RNA splicing underlies high calorie diet-induced cognitive impairment.Molecular psychiatry · 2026Article
- Investigation of the relationship between expanded disability status and swallowing difficulty with swallowing anxiety in multiple sclerosis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
- The association between ultra-processed food exposure and cognition in older adults.GeroScience · 2026Article
- A Ubiquitous Blood Flow Biomarker to Calculate Hypoxic-Ischemic Depolarization Latency in a Mouse Model of Focal Ischemic Stroke: Insight Into Metabolic and Electrophysiological Resilience.Translational stroke research · 2026Article
- The combined effects of probiotic and high-intensity interval training on memory function in high fat diet-fed rats.Behavioral and brain functions : BBF · 2026Article
- Combined Fish Oil and Pine Bark Extract Supplementation Improves Short-Term Memory and the Antioxidant Status in Middle-Aged and Older Adults with Mild Cognitive Impairment: A Randomized Double-Blind, Parallel-Group Pilot Study.Antioxidants (Basel, Switzerland) · 2026Article
- Reversal of early-life high fat diet prevents spatial discrimination deficits corresponding with altered brain inflammatory and metabolic profiles in male C57BL/6J mice.Nutritional neuroscience · 2026Article
- STAT4-dependent regulation of neuroinflammation in atherosclerosis.Physiological reports · 2026Article
- STAT4-dependent regulation of neuroinflammation in atherosclerosis.bioRxiv : the preprint server for biology · 2026Article
- Pharmacological inhibition of IRAK1/4 ameliorates high-fat diet-induced vascular dysfunction and cognitive impairment.Molecular biology reports · 2026Article
- Metabolic alteration in oxylipins and endocannabinoids point to an important role for soluble epoxide hydrolase and inflammation in Alzheimer's disease-finding from Alzheimer's Disease Neuroimaging Initiative.Alzheimer's research & therapy · 2026Article
- Obesity suppresses hippocampal neurogenesis and impairs memory and executive function in a weight and sex-specific manner.Physiology & behavior · 2026Article
- Article
- Modifying Factors of Adult Hippocampal Neurogenesis: A Dorsoventral Perspective in Health and Disease.Cells · 2025Review
- TNF as a mediator of metabolic inflammation and body-brain interaction in obesity-driven neuroinflammation and neurodegeneration.Ageing research reviews · 2025Review
- Volumetric brain alterations associated with a high-fat, high-fructose obesogenic diet: Insights from cross-sectional and longitudinal MRI in mice.Biochemical and biophysical research communications · 2025Article
- Neural Correlates of Eating Habits and Nutritional Behaviors in the General Population: A Systematic Review of Observational Studies.Health science reports · 2025Review
94 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
The prevalence of obesity is growing and now includes at least one-third of the adult population in the United States. As obesity and dementia rates reach epidemic proportions, an even greater interest in the effects of nutrition on the brain have become evident. This review discusses various mechanisms by which a high fat diet and/or obesity can alter the brain and cognition. It is well known that a poor diet and obesity can lead to certain disorders such as type II diabetes, metabolic syndrome, and heart disease. However, long-term effects of obesity on the brain need to be further examined. The contribution of insulin resistance and oxidative stress is briefly reviewed from studies in the current literature. The role of inflammation and vascular alterations are described in more detail due to our laboratory's experience in evaluating these specific factors. It is very likely that each of these factors plays a role in diet-induced and/or obesity-induced cognitive decline.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.