ArticleJournal of translational medicine2013
Wound outcome in combat injuries is associated with a unique set of protein biomarkers.
Article in Journal of translational medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Intranasal delivery of human umbilical cord Wharton's jelly mesenchymal stromal cells restores lung alveolarization and vascularization in experimental bronchopulmonary dysplasia.Stem cells translational medicine · 2020Trial
- Metagenomic features of bioburden serve as outcome indicators in combat extremity wounds.Scientific reports · 2022Article
- Advanced Wound Diagnostics: Toward Transforming Wound Care into Precision Medicine.Advances in wound care · 2022Review
- PBMNCs Treatment in Critical Limb Ischemia and Candidate Biomarkers of Efficacy.Diagnostics (Basel, Switzerland) · 2022Review
- Wound fluid sampling methods for proteomic studies: A scoping review.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2022Article
- Serum protein electrophoresis in healthy and injured southern white rhinoceros (Ceratotherium simum simum).PloS one · 2018Article
- PDGF is a potent initiator of bone formation in a tissue engineered model of pathological ossification.Journal of tissue engineering and regenerative medicine · 2018Article
- Burn wound healing and treatment: review and advancements.Critical care (London, England) · 2015Review
- Current Concepts and Ongoing Research in the Prevention and Treatment of Open Fracture Infections.Advances in wound care · 2015Review
- microRNA-18a is a genetic marker for the early diagnosis of cerebral injury induced by type 2 diabetes.Experimental and therapeutic medicine · 2014Article
- Microbial profiling of combat wound infection through detection microarray and next-generation sequencing.Journal of clinical microbiology · 2014Article
- Proteomic sample preparation for blast wound characterization.Proteome science · 2014Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundThe ability to forecast whether a wound will heal after closure without further debridement(s), would provide substantial benefits to patients with severe extremity trauma.
methodsWound effluent is a readily available material which can be collected without disturbing healthy tissue. For analysis of potential host response biomarkers, forty four serial combat wound effluent samples from 19 patients with either healing or failing traumatic- and other combat-related wounds were examined by 2-D DIGE. Spot map patterns were correlated to eventual wound outcome (healed or wound failure) and analyzed using DeCyder 7.0 and differential proteins identified via LC-MS/MS.
resultsThis approach identified 52 protein spots that were differentially expressed and thus represent candidate biomarkers for this clinical application. Many of these proteins are intimately involved in inflammatory and immune responses. Furthermore, discriminate analysis further refined the 52 differential protein spots to a smaller subset of which successfully differentiate between wounds that will heal and those that will fail and require further surgical intervention with greater than 83% accuracy.
conclusionThese results suggest candidates for a panel of protein biomarkers that may aid traumatic wound care prognosis and treatment. We recommend that this strategy be refined, and then externally validated, in future studies of traumatic wounds.
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