ArticleBiofabrication2013
Biofabrication and testing of a fully cellular nerve graft.
Article in Biofabrication, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed, 202 citations in OpenAlex.
- Biomaterial and Hydrogel Strategies for Regenerative Microenvironment Reconstruction in Peripheral Nerve Conduits.Gels (Basel, Switzerland) · 2025Review
- Embedded 3D bioprinting - An emerging strategy to fabricate biomimetic & large vascularized tissue constructs.Bioactive materials · 2024Review
- Salivary Gland Bioengineering.Bioengineering (Basel, Switzerland) · 2023Review
- Progress in bioprinting technology for tissue regeneration.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2023Review
- Potential Application of Orofacial MSCs in Tissue Engineering Nerve Guidance for Peripheral Nerve Injury Repair.Stem cell reviews and reports · 2023Review
- Fabrication of Multi-Channel Nerve Guidance Conduits Containing Schwann Cells Based on Multi-Material 3D Bioprinting.3D printing and additive manufacturing · 2023Article
- The third dimension of tumor microenvironment-The importance of tumor stroma in 3D cancer models.Experimental biology and medicine (Maywood, N.J.) · 2023Review
- Review
- Prospects for the use of olfactory mucosa cells in bioprinting for the treatment of spinal cord injuries.World journal of clinical cases · 2023Review
- Review
- Robotic-assisted automatedInternational journal of bioprinting · 2023Review
- Development and Application of Three-Dimensional Bioprinting Scaffold in the Repair of Spinal Cord Injury.Tissue engineering and regenerative medicine · 2022Review
- Biofabrication approaches and regulatory framework of metastatic tumor-on-a-chip models for precision oncology.Medicinal research reviews · 2022Review
- Patients' Stem Cells Differentiation in a 3D Environment as a Promising Experimental Tool for the Study of Amyotrophic Lateral Sclerosis.International journal of molecular sciences · 2022Article
- 3D Printed Personalized Nerve Guide Conduits for Precision Repair of Peripheral Nerve Defects.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Review
- A review on 3D printing functional brain model.Biomicrofluidics · 2022Review
- The promising rise of bioprinting in revolutionalizing medical science: Advances and possibilities.Regenerative therapy · 2021Review
- 3D cell aggregate printing technology and its applications.Essays in biochemistry · 2021Review
- 3D Bioprinting of Neural Tissues.Advanced healthcare materials · 2021Review
- Complex 3D bioprinting methods.APL bioengineering · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Rupture of a nerve is a debilitating injury with devastating consequences for the individual's quality of life. The gold standard of repair is the use of an autologous graft to bridge the severed nerve ends. Such repair however involves risks due to secondary surgery at the donor site and may result in morbidity and infection. Thus the clinical approach to repair often involves non-cellular solutions, grafts composed of synthetic or natural materials. Here we report on a novel approach to biofabricate fully biological grafts composed exclusively of cells and cell secreted material. To reproducibly and reliably build such grafts of composite geometry we use bioprinting. We test our grafts in a rat sciatic nerve injury model for both motor and sensory function. In particular we compare the regenerative capacity of the biofabricated grafts with that of autologous grafts and grafts made of hollow collagen tubes by measuring the compound action potential (for motor function) and the change in mean arterial blood pressure as consequence of electrically eliciting the somatic pressor reflex. Our results provide evidence that bioprinting is a promising approach to nerve graft fabrication and as a consequence to nerve regeneration.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.