ArticleNeuro-degenerative diseases2014
Regulation of autophagy by LRRK2 in Caenorhabditis elegans.
Article in Neuro-degenerative diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- The dopaminergic system ofRoyal Society open science · 2025Review
- Roles of LRRK2 and its orthologs in protecting against neurodegeneration and neurodevelopmental defects.Frontiers in cell and developmental biology · 2025Article
- Human Induced Pluripotent Stem Cell Phenotyping and Preclinical Modeling of Familial Parkinson's Disease.Genes · 2022Review
- LRRK2 regulation of immune-pathways and inflammatory disease.Biochemical Society transactions · 2019Review
- Crosstalk between presynaptic trafficking and autophagy in Parkinson's disease.Neurobiology of disease · 2019Review
- The Small GTPase RAC1/CED-10 Is Essential in Maintaining Dopaminergic Neuron Function and Survival Against α-Synuclein-Induced Toxicity.Molecular neurobiology · 2018Article
- LRRK2 kinase regulates α-synuclein propagation via RAB35 phosphorylation.Nature communications · 2018Article
- Models of LRRK2-Associated Parkinson's Disease.Advances in neurobiology · 2017Review
- LRRK2 Promotes Tau Accumulation, Aggregation and Release.Molecular neurobiology · 2016Article
- Activation of the AMPK-ULK1 pathway plays an important role in autophagy during prion infection.Scientific reports · 2015Article
- Defective autophagy in Parkinson's disease: lessons from genetics.Molecular neurobiology · 2015Review
- Aberrant autophagy and parkinsonism: does correction rescue from disease progression?Molecular neurobiology · 2015Review
- Delaying aging is neuroprotective in Parkinson's disease: a genetic analysis inNPJ Parkinson's disease · 2015Article
- Genetic, structural, and molecular insights into the function of ras of complex proteins domains.Chemistry & biology · 2014Review
- Mitochondrial dysfunction driven by the LRRK2-mediated pathway is associated with loss of Purkinje cells and motor coordination deficits in diabetic rat model.Cell death & disease · 2014Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundMutations in LRRK2 (leucine-rich repeat kinase 2) are a common cause of familial Parkinson's disease. However, the mechanisms through which LRRK2 mutations contribute to neurodegeneration are poorly understood.
objectiveWe investigated the effects of WT, G2019S (GS), R1441C (RC) and kinase dead LRRK2 across multiple different cellular compartments in order to gain insight into the breadth of LRRK2 effects on cellular function.
methodsNematodes expressing lgg-1::RFP, hsp1::GFP, hsp4::GFP and hsp6::GFP were crossed to nematode lines expressing WT, GS, RC or kinase dead LRRK2.
resultsWe observed that GS and RC LRRK2 inhibited autophagy, while WT, GS and RC LRRK2 increased the response of the mitochondrial hsp6 reporter to stress. The response of the hsp reporters under basal conditions was more nuanced.
conclusionThese results support a putative role of LRRK2 in the autophagic and mitochondrial systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.