ArticleDiseases of aquatic organisms2013
Paramecium caudatum enhances transmission and infectivity of Mycobacterium marinum and M. chelonae in zebrafish Danio rerio.
Article in Diseases of aquatic organisms, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 56 citations in OpenAlex.
- Protist community sites and structure under two barn management systems at a commercial dairy.Frontiers in microbiomes · 2026Article
- Review
- Assessment of various standard fish diets on gut microbiome of platyfish Xiphophorus maculatus.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2024Article
- Disentangling the link between zebrafish diet, gut microbiome succession, and Mycobacterium chelonae infection.Animal microbiome · 2023Article
- Common laboratory diets differentially influence zebrafish gut microbiome's successional development and sensitivity to pathogen exposure.Research square · 2023Article
- Specific Pathogen Free - A review of strategies in agriculture, aquaculture, and laboratory mammals and how they inform new recommendations for laboratory zebrafish.Research in veterinary science · 2021Review
- Review of diseases and health management in zebrafish Danio rerio (Hamilton 1822) in research facilities.Journal of fish diseases · 2020Review
- Transmission of Mycobacterium chelonae and Mycobacterium marinum in laboratory zebrafish through live feeds.Journal of fish diseases · 2019Article
- High-Throughput Sequencing of the 16S rRNA Gene as a Survey to Analyze the Microbiomes of Free-Living Ciliates Paramecium.Microbial ecology · 2019Article
- Source or Sink: Examining the Role of Biofilms in Transmission of Mycobacterium spp. in Laboratory Zebrafish.Zebrafish · 2019Article
- Skin and Soft Tissue Infections Due to Nontuberculous Mycobacteria.Current infectious disease reports · 2018Review
- Environmental Screening of Aeromonas hydrophila, Mycobacterium spp., and Pseudocapillaria tomentosa in Zebrafish Systems.Journal of visualized experiments : JoVE · 2017Article
- The scales of the zebrafish: host-microbiota interactions from proteins to populations.Current opinion in microbiology · 2017Review
- Comparison of Antemortem and Environmental Samples for Zebrafish Health Monitoring and Quarantine.Journal of the American Association for Laboratory Animal Science : JAALAS · 2017Article
- Development of Quantitative Real-Time PCR Assays for Postmortem Detection ofJournal of the American Association for Laboratory Animal Science : JAALAS · 2017Article
- Strategies to Mitigate a Mycobacterium marinum Outbreak in a Zebrafish Research Facility.Zebrafish · 2016Article
- Review
- Recommendations for Health Monitoring and Reporting for Zebrafish Research Facilities.Zebrafish · 2016Article
- The composition of the zebrafish intestinal microbial community varies across development.The ISME journal · 2016Article
- Successful Replacement of Artemia salina nauplii with Marine Rotifers (Brachionus plicatilis) in the Diet of Preadult Zebrafish (Danio rerio).Zebrafish · 2015Article
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
Mycobacterial infections in laboratory zebrafish Danio rerio are common and widespread in research colonies. Mycobacteria within free-living amoebae have been shown to be transmission vectors for mycobacteriosis. Paramecium caudatum are commonly used as a first food for zebrafish, and we investigated this ciliate's potential to serve as a vector of Mycobacterium marinum and M. chelonae. The ability of live P. caudatum to transmit these mycobacteria to larval, juvenile and adult zebrafish was evaluated. Infections were defined by histologic observation of granulomas containing acid-fast bacteria in extraintestinal locations. In both experiments, fish fed paramecia containing mycobacteria became infected at a higher incidence than controls. Larvae (exposed at 4 d post hatch) fed paramecia with M. marinum exhibited an incidence of 30% (24/80) and juveniles (exposed at 21 d post hatch) showed 31% incidence (14/45). Adult fish fed a gelatin food matrix containing mycobacteria within paramecia or mycobacteria alone for 2 wk resulted in infections when examined 8 wk after exposure as follows: M. marinum OSU 214 47% (21/45), M. marinum CH 47% (9/19), and M. chelonae 38% (5/13). In contrast, fish feed mycobacteria alone in this diet did not become infected, except for 2 fish (5%) in the M. marinum OSU 214 low-dose group. These results demonstrate that P. caudatum can act as a vector for mycobacteria. This provides a useful animal model for evaluation of natural mycobacterial infections and demonstrates the possibility of mycobacterial transmission in zebrafish facilities via contaminated paramecia cultures.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.