ArticleMolecular pharmaceutics2013
Improving lithium therapeutics by crystal engineering of novel ionic cocrystals.
Article in Molecular pharmaceutics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Understanding the Synthon Preferences in Molecular Ionic Cocrystals of Trimethoprim-An Experimental and Computational Study.ACS omega · 2025Article
- Supra-molecular assembly of mebendazolium and di-hydrogen phosphate ions in a new anthelmintic salt.Acta crystallographica. Section E, Crystallographic communications · 2025Article
- Strategies for chiral separation: from racemate to enantiomer.Chemical science · 2023Review
- Article
- Conformational Trimorphism in an Ionic Cocrystal of Hesperetin.Crystal growth & design · 2022Article
- Polymorphism in Ionic Cocrystals Comprising Lithium Salts and l-Proline.Crystal growth & design · 2022Article
- Mechanosynthesis of Higher-Order Cocrystals: Tuning Order, Functionality and Size in Cocrystal Design*.Angewandte Chemie (International ed. in English) · 2021Article
- Amino Acids as the Potential Co-Former for Co-Crystal Development: A Review.Molecules (Basel, Switzerland) · 2021Review
- Efficient Screening for Ternary Molecular Ionic Cocrystals Using a Complementary Mechanosynthesis and Computational Structure Prediction Approach.Chemistry (Weinheim an der Bergstrasse, Germany) · 2020Article
- Comparing the effect of the novel ionic cocrystal of lithium salicylate proline (LISPRO) with lithium carbonate and lithium salicylate on memory and behavior in female APPswe/PS1dE9 Alzheimer's mice.Journal of neuroscience research · 2019Article
- A proposal for coherent nomenclature of multicomponent crystals.Acta crystallographica Section B, Structural science, crystal engineering and materials · 2019Article
- A Review about Regulatory Status and Recent Patents of Pharmaceutical Co-Crystals.Advanced pharmaceutical bulletin · 2018Review
- Engineering Cocrystals of PoorlyWater-Soluble Drugs to Enhance Dissolution in Aqueous Medium.Pharmaceutics · 2018Review
- Nanoparticulated polymeric composites enfolding lithium carbonate as brain drug in persuading depression: an in vivo study.Progress in biomaterials · 2017Article
- LISPRO mitigates β-amyloid and associated pathologies in Alzheimer's mice.Cell death & disease · 2017Article
- Humoral factors in ALS patients during disease progression.Journal of neuroinflammation · 2015Article
- Plasma and Brain Pharmacokinetics of Previously Unexplored Lithium Salts.RSC advances · 2014Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Current United States Food and Drug Administration (FDA)-approved lithium salts are plagued with a narrow therapeutic window. Recent attempts to find alternative drugs have identified new chemical entities, but lithium's polypharmacological mechanisms for treating neuropsychiatric disorders are highly debated and are not yet matched. Thus, re-engineering current lithium solid forms in order to optimize performance represents a low cost and low risk approach to the desired therapeutic outcome. In this contribution, we employed a crystal engineering strategy to synthesize the first ionic cocrystals (ICCs) of lithium salts with organic anions. We are unaware of any previous studies that have assessed the biological efficacy of any ICCs, and encouragingly we found that the new speciation did not negatively affect established bioactivities of lithium. We also observed that lithium ICCs exhibit modulated pharmacokinetics compared to lithium carbonate. Indeed, the studies detailed herein represent an important advancement in a crystal engineering approach to a new generation of lithium therapeutics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.