Trial reportAIDS patient care and STDs2013
Impact of antiretroviral therapy on quality of life in HIV-infected Southeast Asian children in the PREDICT study.
Trial report in AIDS patient care and STDs, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Improved quality of life with immediate versus deferred initiation of antiretroviral therapy in early asymptomatic HIV infection.AIDS (London, England) · 2017Trial
- Quality of life assessment among HIV-positive persons entering the INSIGHT Strategic Timing of AntiRetroviral Treatment (START) trial.HIV medicine · 2015Trial
- Psychosocial Challenges and Coping Strategies Among Adults Living with HIV in Ubungo Municipality, Tanzania: A Qualitative Descriptive Study.The East African health research journal · 2024Article
- The effect of universal testing and treatment for HIV on health-related quality of life - An analysis of data from the HPTN 071 (PopART) cluster randomised trial.SSM - population health · 2023Article
- Alcohol use, suicidality and virologic non-suppression among young adults with perinatally acquired HIV in Thailand: a cross-sectional study.Journal of the International AIDS Society · 2023Article
- Health-related quality of life of children and adolescents living with HIV in Lagos, Nigeria: a cross-sectional study.The Pan African medical journal · 2022Article
- Cortical structural changes related to early antiretroviral therapy (ART) interruption in perinatally HIV-infected children at 5 years of age.IBRO neuroscience reports · 2021Article
- Behavioral Functioning and Quality of Life in South African Children Living with HIV on Antiretroviral Therapy.The Journal of pediatrics · 2020Article
- Impact of HIV on the health-related quality of life in youth with perinatally acquired HIV.World journal of pediatrics : WJP · 2019Article
- Quality of life among perinatally HIV-affected and HIV-unaffected school-aged and adolescent Ugandan children: a multi-dimensional assessment of wellbeing in the post-HAART era.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2017Article
- Pediatric HIV Disclosure Intervention Improves Knowledge and Clinical Outcomes in HIV-Infected Children in Namibia.Journal of acquired immune deficiency syndromes (1999) · 2017Article
- CNS Impact of Perinatal HIV Infection and Early Treatment: the Need for Behavioral Rehabilitative Interventions Along with Medical Treatment and Care.Current HIV/AIDS reports · 2016Review
- Growing-up just like everyone else: key components of a successful pediatric HIV disclosure intervention in Namibia.AIDS (London, England) · 2015Article
- Impact of earlier combination antiretroviral therapy on outcomes in children.Current opinion in HIV and AIDS · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
Abstract
Quality of life (QOL) is an important antiretroviral treatment (ART) outcome. We compared QOL among 299 Thai and Cambodian children ages 1-12 years-old, CD4 15-24% randomized to early (ART at week 0, N=149) versus deferred groups (ART when at CD4 <15%, N=150) and also compared with QOL data from age-matched healthy controls (N=275). Primary caregivers completed PACTG QOL questionnaires at week 0 and every 24 weeks until 144 weeks. Children were enrolled during March 2006 to September 2008. Mean (SD) age of children was 6.3 (2.8) years, 58% were female, 60% were Thai, %CDC N:A:B:C was 2:62:36:0%. During 144 weeks, all children in the early-group and 69 (46%) of deferred-group children started ART. There was no significant difference of QOL scores between treatment groups at baseline (all p>0.05) and at week 144 (all p>0.05). By multivariate analysis, the early-group had higher QOL score changes in five domains, including health perception (p=0.04), physical resilience (p=0.02), psychosocial well-being (p=0.04), social and role functioning (p<0.01), and symptoms (p=0.01) compared to the deferred group. QOL of HIV-infected children in both groups were lower than healthy control in all 7 domains at baseline (all p<0.05) and 5 of 7 domains at weeks 144 (p<0.01). In conclusion, no significant difference of QOL scores between treatment groups. Early ART commencement associated with greater increase of QOL scores over 144 weeks. QOL scores in HIV-infected children were lower than healthy controls.
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