ArticleHypertension (Dallas, Tex. : 1979)2014
Enalapril attenuates the exaggerated sympathetic response to physical stress in prenatally programmed hypertensive rats.
Article in Hypertension (Dallas, Tex. : 1979), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 33 citations in OpenAlex.
- Sex differences in the sensitization of prenatally programmed hypertension.Frontiers in physiology · 2025Review
- Sex Differences in Offspring of Preeclamptic Pregnancies.Current opinion in physiology · 2023Article
- Elevated Vascular Sympathetic Neurotransmission and Remodelling Is a Common Feature in a Rat Model of Foetal Programming of Hypertension and SHR.Biomedicines · 2022Article
- Outcomes With Multidisciplinary Cardiac Rehabilitation in Post-acute Systolic Heart Failure Patients-A Retrospective Propensity Score-Matched Study.Frontiers in cardiovascular medicine · 2022Article
- Sex differences in prenatal programming of hypertension by dexamethasone.Experimental biology and medicine (Maywood, N.J.) · 2021Article
- Kidney and epigenetic mechanisms of salt-sensitive hypertension.Nature reviews. Nephrology · 2021Review
- Interactions of the Brain Renin-Angiotensin-System (RAS) and Inflammation in the Sensitization of Hypertension.Frontiers in neuroscience · 2020Review
- Effect of sex on glomerular filtration rate in programmed rats by prenatal dexamethasone.Physiological reports · 2019Article
- Central nervous system neuroplasticity and the sensitization of hypertension.Nature reviews. Nephrology · 2018Review
- Aberrant DNA methylation of hypothalamic angiotensin receptor in prenatal programmed hypertension.JCI insight · 2018Article
- Role of renal sympathetic nerve activity in prenatal programming of hypertension.Pediatric nephrology (Berlin, Germany) · 2018Review
- Effect of renal denervation on urine angiotensinogen excretion in prenatally programmed rats.Physiological reports · 2017Article
- Transient enalapril attenuates the reduction in glomerular filtration rate in prenatally programmed rats.Physiological reports · 2017Article
- Maternal Gestational Hypertension-Induced Sensitization of Angiotensin II Hypertension Is Reversed by Renal Denervation or Angiotensin-Converting Enzyme Inhibition in Rat Offspring.Hypertension (Dallas, Tex. : 1979) · 2017Article
- Ascorbic Acid Protects against Hypertension through Downregulation of ACE1 Gene Expression Mediated by Histone Deacetylation in Prenatal Inflammation-Induced Offspring.Scientific reports · 2016Article
- Developmental Programming of Hypertension: Physiological Mechanisms.Hypertension (Dallas, Tex. : 1979) · 2016Review
- Dynamic exercise training prevents exercise pressor reflex overactivity in spontaneously hypertensive rats.American journal of physiology. Heart and circulatory physiology · 2015Article
- Challenges and opportunities in developmental integrative physiology.Comparative biochemistry and physiology. Part A, Molecular & integrative physiology · 2015Review
- Muscle mechanoreflex overactivity in hypertension: a role for centrally-derived nitric oxide.Autonomic neuroscience : basic & clinical · 2015Review
- Transient Exposure of Enalapril Normalizes Prenatal Programming of Hypertension and Urinary Angiotensinogen Excretion.PloS one · 2015Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Adulthood hypertension can be prenatally programmed by maternal dietary protein deprivation. We have shown that the sympathetically mediated pressor response to physical stress is exaggerated in prenatally programmed hypertensive (PPH) rats. The mechanisms underlying this abnormal responsiveness remain undetermined. The renin-angiotensin system is known to affect sympathetic nerve activity. Therefore, the purpose of this study was to determine whether inhibition of the renin-angiotensin system attenuates the enhanced sympathetic and pressor responses to physical stress in PPH rats. Changes in renal sympathetic nerve activity and blood pressure in response to hindlimb contraction, hindlimb stretch, and hindlimb intra-arterial capsaicin administration were assessed in control and PPH rats treated (from age 3 weeks) with either vehicle or the angiotensin-converting enzyme inhibitor enalapril. Conscious resting systolic arterial pressure was significantly greater in PPH rats (142±5 mm Hg) than in control (128±2 mm Hg) after vehicle treatment (P<0.05). Resting systolic pressure was reduced by enalapril treatment in PPH rats (125±2 mm Hg) but had no effect in control (128±2 mm Hg). The pressor and renal sympathetic responses to muscle contraction and stretch were significantly higher in decerebrate PPH rats than in decerebrate control in vehicle-treated groups. Responses to capsaicin were variable. Enalapril significantly attenuated the enhanced contraction-induced elevations in mean pressure (vehicle, 45±6 mm Hg; enalapril, 21±3 mm Hg) and renal sympathetic activity (vehicle, 175±22%; enalapril, 89±23%) in PPH rats. Its effects were similar on responses to stretch in PPH rats but were equivocal during capsaicin administration. The results suggest that the renin-angiotensin system contributes to the enhancement of the renal sympathetic and pressor responses to physical stress in PPH rats.
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