ArticleProceedings of the National Academy of Sciences of the United States of America2013
Glycogenomics as a mass spectrometry-guided genome-mining method for microbial glycosylated molecules.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
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Who cites it
61 citing papers in PubMed.
- Unveiling the genomes and secondary metabolomes ofFrontiers in microbiology · 2026Article
- A metabologenomics strategy for rapid discovery of polyketides derived from modular polyketide synthases.Chemical science · 2025Article
- Metabolic picture of microbial interaction: chemical crosstalk during co-cultivation between three dominant genera of bacteria and fungi in medicinal plants rhizosphere.Metabolomics : Official journal of the Metabolomic Society · 2024Article
- Unusual Sesquiterpenes fromJournal of natural products · 2024Article
- Enantioselective Transfer Hydrogenative Cycloaddition Unlocks the Total Synthesis of SF2446 B3: An Aglycone of Arenimycin and SF2446 Type II Polyketide Antibiotics.Journal of the American Chemical Society · 2023Article
- Discovery and biosynthetic assessment of 'Microbial genomics · 2023Article
- Microbial Metabolites Annotation by Mass Spectrometry-Based Metabolomics.Advances in experimental medicine and biology · 2023Article
- Strategies to access biosynthetic novelty in bacterial genomes for drug discovery.Nature reviews. Drug discovery · 2022Review
- Mass spectrometry-based metabolomics in microbiome investigations.Nature reviews. Microbiology · 2022Review
- Metabolomics and genomics in natural products research: complementary tools for targeting new chemical entities.Natural product reports · 2021Review
- Mining genomes to illuminate the specialized chemistry of life.Nature reviews. Genetics · 2021Review
- Microbial Oligosaccharides with Biomedical Applications.Marine drugs · 2021Review
- Coupling Mass Spectral and Genomic Information to Improve Bacterial Natural Product Discovery Workflows.Marine drugs · 2021Review
- Leveraging orthogonal mass spectrometry based strategies for comprehensive sequencing and characterization of ribosomal antimicrobial peptide natural products.Natural product reports · 2021Review
- Integration of molecular networking and fingerprint analysis for studying constituents in Microctis Folium.PloS one · 2020Article
- Structure Elucidation of Macrolide Antibiotics Using MSJournal of the American Society for Mass Spectrometry · 2019Article
- Toward a global picture of bacterial secondary metabolism.Journal of industrial microbiology & biotechnology · 2019Article
- CytA, a reductase in the cytorhodin biosynthesis pathway, inactivates anthracycline drugs inCommunications biology · 2019Article
- Genome and metabolome mining of marine obligate Salinisporsatrains to discover new natural products.Turkish journal of biology = Turk biyoloji dergisi · 2019Article
- Dereplication of microbial metabolites through database search of mass spectra.Nature communications · 2018Article
1 more citing papers are in PubMed but not listed here.
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7 authors.
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Abstract
Glycosyl groups are an essential mediator of molecular interactions in cells and on cellular surfaces. There are very few methods that directly relate sugar-containing molecules to their biosynthetic machineries. Here, we introduce glycogenomics as an experiment-guided genome-mining approach for fast characterization of glycosylated natural products (GNPs) and their biosynthetic pathways from genome-sequenced microbes by targeting glycosyl groups in microbial metabolomes. Microbial GNPs consist of aglycone and glycosyl structure groups in which the sugar unit(s) are often critical for the GNP's bioactivity, e.g., by promoting binding to a target biomolecule. GNPs are a structurally diverse class of molecules with important pharmaceutical and agrochemical applications. Herein, O- and N-glycosyl groups are characterized in their sugar monomers by tandem mass spectrometry (MS) and matched to corresponding glycosylation genes in secondary metabolic pathways by a MS-glycogenetic code. The associated aglycone biosynthetic genes of the GNP genotype then classify the natural product to further guide structure elucidation. We highlight the glycogenomic strategy by the characterization of several bioactive glycosylated molecules and their gene clusters, including the anticancer agent cinerubin B from Streptomyces sp. SPB74 and an antibiotic, arenimycin B, from Salinispora arenicola CNB-527.
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