ArticleProceedings of the National Academy of Sciences of the United States of America2013
Long-term inhibitory plasticity in visual cortical layer 4 switches sign at the opening of the critical period.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Neuron type-specific optogenetic stimulation for differential stroke recovery in chronic capsular infarct.Experimental & molecular medicine · 2024Article
- Synaptic scaling of corticostriatal circuits underlies hyperactivity in GABA Transporter-1 deficient mice.iScience · 2023Article
- A circuit mechanism for independent modulation of excitatory and inhibitory firing rates after sensory deprivation.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Lifelong changes of neurotransmitter receptor expression and debilitation of hippocampal synaptic plasticity following early postnatal blindness.Scientific reports · 2022Article
- Inhibitory stabilization and cortical computation.Nature reviews. Neuroscience · 2021Review
- Synaptic Plasticity in Cortical Inhibitory Neurons: What Mechanisms May Help to Balance Synaptic Weight Changes?Frontiers in cellular neuroscience · 2020Review
- Distinct Heterosynaptic Plasticity in Fast Spiking and Non-Fast-Spiking Inhibitory Neurons in Rat Visual Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Article
- Eye opening differentially modulates inhibitory synaptic transmission in the developing visual cortex.eLife · 2017Article
- Emerging Mechanisms Underlying Dynamics of GABAergic Synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Review
- Neurophysiology and Regulation of the Balance Between Excitation and Inhibition in Neocortical Circuits.Biological psychiatry · 2017Review
- GABAB receptor-dependent bidirectional regulation of critical period ocular dominance plasticity in cats.PloS one · 2017Article
- Distinct and developmentally regulated activity-dependent plasticity at descending glutamatergic synapses on flexor and extensor motoneurons.Scientific reports · 2016Article
- Differential maturation of vesicular glutamate and GABA transporter expression in the mouse auditory forebrain during the first weeks of hearing.Brain structure & function · 2016Article
- The onset of visual experience gates auditory cortex critical periods.Nature communications · 2016Article
- Article
- Whisker Deprivation Drives Two Phases of Inhibitory Synapse Weakening in Layer 4 of Rat Somatosensory Cortex.PloS one · 2016Article
- Adult cortical plasticity following injury: Recapitulation of critical period mechanisms?Neuroscience · 2014Review
- Deprivation-induced strengthening of presynaptic and postsynaptic inhibitory transmission in layer 4 of visual cortex during the critical period.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Shaping inhibition: activity dependent structural plasticity of GABAergic synapses.Frontiers in cellular neuroscience · 2014Review
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Authors and funding
3 authors.
Funding
Abstract
Sensory microcircuits are refined by experience during windows of heightened plasticity termed "critical periods" (CPs). In visual cortex the effects of visual deprivation change dramatically at the transition from the pre-CP to the CP, but the cellular plasticity mechanisms that underlie this change are poorly understood. Here we show that plasticity at unitary connections between GABAergic Fast Spiking (FS) cells and Star Pyramidal (SP) neurons within layer 4 flips sign at the transition between the pre-CP and the CP. During the pre-CP, coupling FS firing with SP depolarization induces long-term depression of inhibition at this synapse, whereas the same protocol induces long-term potentiation of inhibition at the opening of the CP. Despite being of opposite sign, both forms of plasticity share expression characteristics--a change in coefficient of variation with no change in paired-pulse ratio--and depend on GABAB receptor signaling. Finally, we show that the reciprocal SP → FS synapse also acquires the ability to undergo long-term potentiation at the pre-CP to CP transition. Thus, at the opening of the CP, there are coordinated changes in plasticity that allow specific patterns of activity within layer 4 to potentiate feedback inhibition by boosting the strength of FS ↔ SP connections.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.