ArticleProceedings of the National Academy of Sciences of the United States of America2013
Epileptic baboons have lower numbers of neurons in specific areas of cortex.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- AAV-mediated GPR173 gene therapy attenuates long-term refractory epilepsy by enhancing synaptic GABAActa pharmacologica Sinica · 2026Article
- Genetic Animal Models of Idiopathic Generalized Epilepsies: What Can We Learn from Them?Biomedicines · 2025Review
- Quantitative MRI Measures and Cognitive Function in People With Drug-Resistant Juvenile Myoclonic Epilepsy.Neurology · 2024Article
- Dehydroepiandrosterone Attenuates Astroglial Activation, Neuronal Loss and Dendritic Degeneration in Iron-Induced Post-Traumatic Epilepsy.Brain sciences · 2023Article
- Chemogenetic attenuation of cortical seizures in nonhuman primates.Nature communications · 2023Article
- Neuroimaging in the Epileptic Baboon.Frontiers in veterinary science · 2022Review
- Neurobehavioural comorbidities of epilepsy: towards a network-based precision taxonomy.Nature reviews. Neurology · 2021Review
- The baboon in epilepsy research: Revelations and challenges.Epilepsy & behavior : E&B · 2021Review
- Developmental MRI markers cosegregate juvenile patients with myoclonic epilepsy and their healthy siblings.Neurology · 2019Article
- Epilepsy in nonhuman primates.Epilepsia · 2019Review
- A method for u-fiber quantification from 7 T diffusion-weighted MRI data tested in patients with nonlesional focal epilepsy.Neuroreport · 2017Article
- Resting-state functional connectivity changes due to acute and short-term valproic acid administration in the baboon model of GGE.NeuroImage. Clinical · 2017Article
- Voxel-based morphometry in epileptic baboons: Parallels to human juvenile myoclonic epilepsy.Epilepsy research · 2016Article
- Modeling the effective connectivity of the visual network in healthy and photosensitive, epileptic baboons.Brain structure & function · 2016Article
- Cortical cell and neuron density estimates in one chimpanzee hemisphere.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Resting-state functional connectivity in the baboon model of genetic generalized epilepsy.Epilepsia · 2015Article
- How to count cells: the advantages and disadvantages of the isotropic fractionator compared with stereology.Cell and tissue research · 2015Article
- Animal models in epilepsy research: legacies and new directions.Nature neuroscience · 2015Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
Epilepsy is characterized by recurrent seizure activity that can induce pathological reorganization and alter normal function in neocortical networks. In the present study, we determined the numbers of cells and neurons across the complete extent of the cortex for two epileptic baboons with naturally occurring seizures and two baboons without epilepsy. Overall, the two epileptic baboons had a 37% average reduction in the number of cortical neurons compared with the two nonepileptic baboons. The loss of neurons was variable across cortical areas, with the most pronounced loss in the primary motor cortex, especially in lateral primary motor cortex, representing the hand and face. Less-pronounced reductions of neurons were found in other parts of the frontal cortex and in somatosensory cortex, but no reduction was apparent in the primary visual cortex and little in other visual areas. The results provide clear evidence that epilepsy in the baboon is associated with considerable reduction in the numbers of cortical neurons, especially in frontal areas of the cortex related to motor functions. Whether or not the reduction of neurons is a cause or an effect of seizures needs further investigation.
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