Evidence map›Paper›PMID 24190961›Full record

ArticleCirculation2014

Role of small-conductance calcium-activated potassium channels in atrial electrophysiology and fibrillation in the dog.

Xiao-Yan Qi, Jonas G Diness, Bianca J J M Brundel, Xiao-Bo Zhou, Patrice Naud, Chia-Tung Wu, Hai Huang, Masahide Harada, Mona Aflaki, Dobromir Dobrev and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Circulation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers.

0numbers the graph read from it
0cells of the map it votes in
91citing papers in PubMed
12.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

91 citing papers in PubMed, 171 citations in OpenAlex.

  1. Inhibition of the KNature medicine · 2024
    Trial
  2. First Clinical Study with AP30663 - a KClinical and translational science · 2020
    Trial
  3. Trial
  4. Small-conductance CaThe Journal of physiology · 2026
    Review
  5. Review
  6. Article
  7. Article
  8. NaInternational journal of cardiology. Heart & vasculature · 2025
    Article
  9. Activation of Small Conductance CaInternational journal of molecular sciences · 2025
    Article
  10. Article
  11. Review
  12. Review
  13. Review
  14. Up-regulated small-conductance calcium-activated potassium currents contribute to atrial arrhythmogenesis in high-fat feeding mice.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023
    Article
  15. Dual effects of the small-conductance CaAmerican journal of physiology. Heart and circulatory physiology · 2023
    Article
  16. Towards Improved HumanBiomedicines · 2023
    Review
  17. Small-conductance calcium-activated potassium channels in the heart: expression, regulation and pathological implications.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023
    Review
  18. Advances in basic and translational research in atrial fibrillation.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023
    Review
  19. Enhanced CaCirculation research · 2023
    Article
  20. Review

31 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 3 countries.

Xiao-Yan QiResearch Center (X.-Y.Q., P.N., C.-T.W., H.H., M.H., M.A., S.N.), Montreal Heart Institute, Université de Montréal, Montreal, Quebec, Canada; Cardiac and Circulatory Research Section (J.G.D., M.G.), Faculty of Health Sciences, University of Copenhagen and Acesion Pharma, Copenhagen, Denmark; Department of Clinical Pharmacology (B.J.J.M.B.), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Division of Experimental Cardiology (X.-B.Z., D.D.), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; Chang-Gung Memorial Hospital and University Taoyuan (C.-T.W.), Taoyuan, Taiwan, China; Institute of Pharmacology (D.D.), Faculty of Medicine, University Duisburg-Essen, Essen, Germany.
Jonas G Diness
Bianca J J M Brundel
Xiao-Bo Zhou
Patrice Naud
Chia-Tung Wu
Hai Huang
Masahide Harada
Mona Aflaki
Dobromir Dobrev
Morten Grunnet
Stanley Nattel
Taoyuan Chang Gung Memorial Hospital · TWUniversity Medical Center Groningen · NLUniversity Medical Centre Mannheim · DEHeidelberg University · DEUniversity Hospital Heidelberg · DE

Funding

CIHR MOP 44365Wellcome Trust 100406
6 · The paper itself

Abstract

backgroundRecent evidence points to functional Ca²⁺-dependent K⁺ (SK) channels in the heart that may govern atrial fibrillation (AF) risk, but the underlying mechanisms are unclear. This study addressed the role of SK channels in atrial repolarization and AF persistence in a canine AF model. METHODS AND

resultsElectrophysiological variables were assessed in dogs subjected to atrial remodeling by 7-day atrial tachypacing (AT-P), as well as controls. Ionic currents and single-channel properties were measured in isolated canine atrial cardiomyocytes by patch clamp. NS8593, a putative selective SK blocker, suppressed SK current with an IC₅₀ of ≈5 μmol/L, without affecting Na⁺, Ca²⁺, or other K⁺ currents. Whole-cell SK current sensitive to NS8593 was significantly larger in pulmonary vein (PV) versus left atrial (LA) cells, without a difference in SK single-channel open probability (P(o)), whereas AT-P enhanced both whole-cell SK currents and single-channel P(o). SK-current block increased action potential duration in both PV and LA cells after AT-P; but only in PV cells in absence of AT-P. SK2 expression was more abundant at both mRNA and protein levels for PV versus LA in control dogs, in both control and AT-P; AT-P upregulated only SK1 at the protein level. Intravenous administration of NS8593 (5 mg/kg) significantly prolonged atrial refractoriness and reduced AF duration without affecting the Wenckebach cycle length, left ventricular refractoriness, or blood pressure.

conclusionsSK currents play a role in canine atrial repolarization, are larger in PVs than LA, are enhanced by atrial-tachycardia remodeling, and appear to participate in promoting AF maintenance. These results are relevant to the potential mechanisms underlying the association between SK single-nucleotide polymorphisms and AF and suggest SK blockers as potentially interesting anti-AF drugs.

Indexed as

1-NaphthylamineAnimalsAtrial FibrillationDisease Models, AnimalDogsElectrophysiological PhenomenaElectrophysiologic Techniques, CardiacHeart AtriaMyocytes, CardiacPatch-Clamp TechniquesPotassium Channel BlockersPulmonary VeinsSmall-Conductance Calcium-Activated Potassium Channels1-NaphthylaminePotassium Channel Blockers(R)-N-(benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphthylamineSmall-Conductance Calcium-Activated Potassium Channelsaction potentialsanti-arrhythmia agentselectrophysiologyion channels

Identifiers

PMID24190961
OpenAlexW2086257379

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.