ArticleGenome research2014
A fine-scale recombination map of the human-chimpanzee ancestor reveals faster change in humans than in chimpanzees and a strong impact of GC-biased gene conversion.
Article in Genome research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 42 citations in OpenAlex.
- Towards the genomic sequence code of DNA fragility for machine learning.Nucleic acids research · 2024Article
- Understanding the Genetic Basis of Variation in Meiotic Recombination: Past, Present, and Future.Molecular biology and evolution · 2024Review
- High prevalence of PRDM9-independent recombination hotspots in placental mammals.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Evolutionary dynamics of pseudoautosomal region 1 in humans and great apes.Genome biology · 2022Article
- Article
- Runaway GC Evolution in Gerbil Genomes.Molecular biology and evolution · 2020Article
- Reduced meiotic recombination in rhesus macaques and the origin of the human recombination landscape.PloS one · 2020Article
- Inference of recombination maps from a single pair of genomes and its application to ancient samples.PLoS genetics · 2019Article
- Historical Meiotic Crossover Hotspots Fueled Patterns of Evolutionary Divergence in Rice.The Plant cell · 2019Article
- PRDM9, a driver of the genetic map.PLoS genetics · 2018Review
- Fine-Scale Recombination Maps of Fungal Plant Pathogens Reveal Dynamic Recombination Landscapes and Intragenic Hotspots.Genetics · 2018Article
- Review
- Detecting ancient positive selection in humans using extended lineage sorting.Genome research · 2017Article
- Article
- Evidence that the rate of strong selective sweeps increases with population size in the great apes.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Joint Prediction of the Effective Population Size and the Rate of Fixation of Deleterious Mutations.Genetics · 2016Article
- The Time Scale of Recombination Rate Evolution in Great Apes.Molecular biology and evolution · 2016Article
- Massive interstitial copy-neutral loss-of-heterozygosity as evidence for cancer being a disease of the DNA-damage response.BMC medical genomics · 2015Article
- GC-Content evolution in bacterial genomes: the biased gene conversion hypothesis expands.PLoS genetics · 2015Article
- Germline methylation patterns determine the distribution of recombination events in the dog genome.Genome biology and evolution · 2014Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recombination is a major determinant of adaptive and nonadaptive evolution. Understanding how the recombination landscape has evolved in humans is thus key to the interpretation of human genomic evolution. Comparison of fine-scale recombination maps of human and chimpanzee has revealed large changes at fine genomic scales and conservation over large scales. Here we demonstrate how a fine-scale recombination map can be derived for the ancestor of human and chimpanzee, allowing us to study the changes that have occurred in human and chimpanzee since these species diverged. The map is produced from more than one million accurately determined recombination events. We find that this new recombination map is intermediate to the maps of human and chimpanzee but that the recombination landscape has evolved more rapidly in the human lineage than in the chimpanzee lineage. We use the map to show that recombination rate, through the effect of GC-biased gene conversion, is an even stronger determinant of base composition evolution than previously reported.
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