ArticleJournal of cell science2013
Flow-dependent cellular mechanotransduction in atherosclerosis.
Article in Journal of cell science, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 82 citations in OpenAlex.
- Principles and regulation of mechanosensing.Journal of cell science · 2024Review
- Hemodynamics and Wall Mechanics of Vascular Graft Failure.Arteriosclerosis, thrombosis, and vascular biology · 2024Review
- Squishy matters - Corneal mechanobiology in health and disease.Progress in retinal and eye research · 2024Review
- Extracellular Matrix Remodeling in Vascular Disease: Defining Its Regulators and Pathological Influence.Arteriosclerosis, thrombosis, and vascular biology · 2023Review
- Review
- Review
- Development and Preliminary Testing of Porcine Blood-Derived Endothelial-like Cells for Vascular Tissue Engineering Applications: Protocol Optimisation and Seeding of Decellularised Human Saphenous Veins.International journal of molecular sciences · 2022Article
- Review
- Heparan sulfate proteoglycan glypican-1 and PECAM-1 cooperate in shear-induced endothelial nitric oxide production.Scientific reports · 2021Article
- SMAD6 transduces endothelial cell flow responses required for blood vessel homeostasis.Angiogenesis · 2021Article
- MEF2 (Myocyte Enhancer Factor 2) Is Essential for Endothelial Homeostasis and the Atheroprotective Gene Expression Program.Arteriosclerosis, thrombosis, and vascular biology · 2021Article
- Functional lipidomics of vascular endothelial cells in response to laminar shear stress.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- Wnt2 Contributes to the Development of Atherosclerosis.Frontiers in cardiovascular medicine · 2021Article
- CLEC-2-dependent platelet subendothelial accumulation by flow disturbance contributes to atherogenesis in mice.Theranostics · 2021Article
- Inflammatory Cytokines and Atherosclerotic Plaque Progression. Therapeutic Implications.Current atherosclerosis reports · 2020Review
- Stress fiber anisotropy contributes to force-mode dependent chromatin stretching and gene upregulation in living cells.Nature communications · 2020Article
- YAP and the RhoC regulator ARHGAP18, are required to mediate flow-dependent endothelial cell alignment.Cell communication and signaling : CCS · 2020Article
- Extracorporeal shock waves protect cardiomyocytes from doxorubicin-induced cardiomyopathy by upregulating survivin via the integrin-ILK-Akt-Sp1/p53 axis.Scientific reports · 2019Article
- ARHGAP18: A Flow-Responsive Gene That Regulates Endothelial Cell Alignment and Protects Against Atherosclerosis.Journal of the American Heart Association · 2019Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Atherosclerosis depends on risk factors such as hyperlipidemia, smoking, hypertension and diabetes. Although these risk factors are relatively constant throughout the arterial circulation, atherosclerotic plaques occur at specific sites where flow patterns are disturbed, with lower overall magnitude and complex changes in speed and direction. Research over the past few decades has provided new insights into the cellular mechanisms of force transduction and how mechanical effects act in concert with conventional risk factors to mediate plaque formation and progression. This Commentary summarizes our current understanding of how mechanotransduction pathways synergize with conventional risk factors in atherosclerosis. We attempt to integrate cellular studies with animal and clinical data, and highlight major questions that need to be answered to develop more effective therapies.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.