ArticleNeuroradiology2014
Disc degeneration and chronic low back pain: an association which becomes nonsignificant when endplate changes and disc contour are taken into account.
Article in Neuroradiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Changes of trunk muscle stiffness in individuals with low back pain: a systematic review with meta-analysis.BMC musculoskeletal disorders · 2024Pooled it
- MRI Findings of Disc Degeneration are More Prevalent in Adults with Low Back Pain than in Asymptomatic Controls: A Systematic Review and Meta-Analysis.AJNR. American journal of neuroradiology · 2015Pooled it
- Systematic literature review of imaging features of spinal degeneration in asymptomatic populations.AJNR. American journal of neuroradiology · 2015Pooled it
- Differential patient responses to spinal manipulative therapy and their relation to spinal degeneration and post-treatment changes in disc diffusion.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2019Trial
- Article
- Fast high-quality MRI protocol of the lumbar spine with deep learning-based algorithm: an image quality and scanning time comparison with standard protocol.Skeletal radiology · 2024Article
- MRI image features with an evident relation to low back pain: a narrative review.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2023Review
- The Association of MRI Findings and Long-Term Disability in Patients With Chronic Low Back Pain.Global spine journal · 2021Article
- Imaging features of the aging spine.Polish journal of radiology · 2021Review
- An exploratory study of different definitions and thresholds for lumbar disc degeneration assessed by MRI and their associations with low back pain using data from a cohort study of a general population.BMC musculoskeletal disorders · 2020Article
- Current evidence for spinal X-ray use in the chiropractic profession: a narrative review.Chiropractic & manual therapies · 2018Review
- Characteristics of Modic changes in cervical kyphosis and their association with axial neck pain.Journal of pain research · 2017Article
- Towards consistency for magnetic resonance (MR) relaxometry of lumbar intervertebral discs.Quantitative imaging in medicine and surgery · 2016Article
- Degenerative Pathways of Lumbar Motion Segments--A Comparison in Two Samples of Patients with Persistent Low Back Pain.PloS one · 2016Article
- Tissue Engineering a Biological Repair Strategy for Lumbar Disc Herniation.BioResearch open access · 2015Review
- Mesenchymal stem cells: potential application in intervertebral disc regeneration.Translational pediatrics · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 8 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe objective of this study was to assess the association between severe disc degeneration (DD) and low back pain (LBP).
methodsA case-control study was conducted with 304 subjects, aged 35-50, recruited in routine clinical practice across six hospitals; 240 cases (chronic LBP patients with a median pain duration of 46 months) and 64 controls (asymptomatic subjects without any lifetime history of significant LBP). The following variables were assessed once, using previously validated methods: gender, age, body mass index (BMI), lifetime smoking exposure, degree of physical activity, severity of LBP, disability, and findings on magnetic resonance (MRI) (disc degeneration, Modic changes (MC), disc protrusion/hernia, annular tears, spinal stenosis, and spondylolisthesis). Radiologists who interpreted MRI were blinded to the subjects' characteristics. A multivariate logistic regression model assessed the association between severe DD and chronic LBP, adjusting for gender, age, BMI, physical activity, MC, disc protrusion/hernia, and spinal stenosis.
resultsSevere DD at ≥1 level was found in 46.9 % of the controls and 65.8 % of the cases. Crude odds ratio (95 % CI), for suffering chronic LBP when having severe DD, was 2.06 (1.05; 4.06). After adjusting for "MC" and "disc protrusion/hernia," it was 1.81 (0.81; 4.05).
conclusionsThe association between severe DD and LBP ceases to be significant when adjusted for MC and disc protrusion/hernia. These results do not support that DD as a major cause of chronic LBP.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.