ArticleIrish journal of medical science2014
Association of oxysterol binding protein-related protein 9 polymorphism with cerebral infarction in Hunan Han population.
Article in Irish journal of medical science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.
- The Role of Genetics in Stroke Risk and Outcome: A Review of Current Evidence.Brain and behavior · 2025Pooled it
- Bridging the molecular and biological functions of the oxysterol-binding protein family.Cellular and molecular life sciences : CMLS · 2018Review
- Leu125Val polymorphism of platelet endothelial cell adhesion molecule-1 is associated with atherosclerotic cerebral infarction in Chinese Han population.International journal of clinical and experimental medicine · 2014Article
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5 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundOxysterol binding protein-related protein 9 (ORP9) may be related to the pathogenesis of cerebral infarction since it is closely related with glucose and lipid metabolism. The present study was designed to investigate the genetic relationship between ORP9 gene polymorphisms and cerebral infarction (CI) in Hunan Han population.
methodsTotal 544 cerebral infarction patients (60.0 ± 10.3 years) and 284 healthy controls (59.0 ± 9.5 years) were enrolled. Sociodemographic and clinical data of the subjects, such as age, gender, body mass index, smoking, drinking, diabetes mellitus, hypertension, systolic and diastolic blood pressures, fasting blood glucose, triglycerides, total cholesterol, low-density and high-density lipoprotein were recorded, and two single-nucleotide polymorphisms (SNPs) of ORP9 gene including rs856600 and rs768529 with high mutation annotation format (MAF) values of 0.103 and 0.485 were studied by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
resultsNo statistical difference was observed in allele distributions and frequencies of the two SNPs between control and CI groups. However, the percentage of atherosclerosis in CI group was significantly higher than that in the control group (p < 0.001). The frequencies of the TT genotype and T allele of rs768529 were significantly higher in patients with vulnerable plaque than those in patients with stable plaque (p < 0.001, p = 0.002). Logistic association analysis showed no correlations between cerebral infarction and different alleles (p > 0.05).
conclusionT allele of rs768529 may be a risk factor for the formation of the carotid vulnerable plaque in Chinese Hunan Han population.
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