ArticleJournal of Zhejiang University. Science. B2013
Neuroprotective effects of flavonoids extracted from licorice on kainate-induced seizure in mice through their antioxidant properties.
Article in Journal of Zhejiang University. Science. B, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 35 citations in OpenAlex.
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- Evaluation of the Anxiolytic and Anti-Epileptogenic Potential ofAntioxidants (Basel, Switzerland) · 2022Article
- The Anticonvulsant Effect of a Novel Indole-Related Compound in the Kainate-Induced Status Epilepticus in Mice: The Role of the Antioxidant and Anti-inflammatory Mechanism.Neurochemical research · 2022Article
- Review
- Awareness and current knowledge of epilepsy.Metabolic brain disease · 2020Review
- Synthesis of Chromen-4-One-Oxadiazole Substituted Analogs as PotentMolecules (Basel, Switzerland) · 2019Article
- Unexpected Effects of Acetylcholine Precursors on Pilocarpine Seizure- Induced Neuronal Death.Current neuropharmacology · 2018Review
- Effect of tualang honey against KA-induced oxidative stress and neurodegeneration in the cortex of rats.BMC complementary and alternative medicine · 2017Article
- Status epilepticus: Using antioxidant agents as alternative therapies.Experimental and therapeutic medicine · 2016Article
- Ameliorating effect of luteolin on memory impairment in an Alzheimer's disease model.Molecular medicine reports · 2016Article
- Kainic Acid-Induced Excitotoxicity Experimental Model: Protective Merits of Natural Products and Plant Extracts.Evidence-based complementary and alternative medicine : eCAM · 2015Review
- [Effect of licorice flavonoids on kainic acid-induced seizure in mice].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2015Article
- Effects of Flavonoid Compounds on β-amyloid-peptide-induced Neuronal Death in Cultured Mouse Cortical Neurons.Chonnam medical journal · 2014Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A relationship between status epilepticus (SE) and oxidative stress has recently begun to be recognized. To explore whether the flavonoids extracted from licorice (LFs) have any protective effect on kainate (KA)-induced seizure in mice, we treated mice with LFs before and after KA injection. In KA-treated mice, we found that superoxide dismutase (SOD) activity decreased immediately after the onset of seizure at 1 h and then increased at 6 h. It returned to baseline 1 d after seizure and then increased again at 3, 7, and 28 d, while malondialdehyde (MDA) content remained at a high level at 1 h, 6 h, 3 d, 7 d, and 28 d, indicating a more oxidized status related to the presence of more reactive oxygen species (ROS). Treatment with LFs before KA injection reversed the seizure-induced change in SOD activity and MDA content at 1 h, 6 h, 3 d, 7 d, and 28 d. Treatment with LFs after seizure decreased KA-induced SOD activity and MDA content at 7 and 28 d. Also, LF pre- and post-KA treatments decreased seizure-induced neuronal cell death. Subsequently, Morris water maze tests revealed that the escape latency was significantly decreased and the number of target quadrant crossings was markedly increased in the LF-treated groups. Thus, our data indicate that LFs have protective effects on seizure-induced neuronal cell death and cognitive impairment through their anti-oxidative effects.
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