ArticleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2014
TGFβ inducible early gene-1 plays an important role in mediating estrogen signaling in the skeleton.
Article in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 19 citations in OpenAlex.
- Krüppel-like factor 10 (KLF10) as a critical signaling mediator: Versatile functions in physiological and pathophysiological processes.Genes & diseases · 2023Review
- Deciphering the Role ofJournal of biomedical science and engineering · 2022Article
- Krüppel-like factor 10 regulates the contractile properties of skeletal muscle fibers in mice.Muscle & nerve · 2021Article
- 17α-Estradiol prevents ovariectomy-mediated obesity and bone loss.Experimental gerontology · 2020Article
- Sclerostin antibody treatment rescues the osteopenic bone phenotype of TGFβ inducible early gene-1 knockout female mice.Journal of cellular physiology · 2020Article
- Skeletal impact of 17β-estradiol in T cell-deficient mice: age-dependent bone effects and osteosarcoma formation.Clinical & experimental metastasis · 2020Article
- Identification of key microRNAs and target genes for the diagnosis of bone nonunion.Molecular medicine reports · 2020Article
- Development of a novel multiphysical approach for the characterization of mechanical properties of musculotendinous tissues.Scientific reports · 2019Article
- Impacts of Psychological Stress on Osteoporosis: Clinical Implications and Treatment Interactions.Frontiers in psychiatry · 2019Review
- Review
- TIEG and estrogen modulate SOST expression in the murine skeleton.Journal of cellular physiology · 2018Article
- Role of estrogen receptor signaling in skeletal response to leptin in femaleThe Journal of endocrinology · 2017Article
- TIEG1 modulates β-catenin sub-cellular localization and enhances Wnt signaling in bone.Nucleic acids research · 2017Article
- TIEG1 enhances Osterix expression and mediates its induction by TGFβ and BMP2 in osteoblasts.Biochemical and biophysical research communications · 2016Article
- Klf10 regulates odontoblast differentiation and mineralization via promoting expression of dentin matrix protein 1 and dentin sialophosphoprotein genes.Cell and tissue research · 2016Article
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
Abstract
TGFβ Inducible Early Gene-1 (TIEG1) knockout (KO) mice display a sex-specific osteopenic phenotype characterized by low bone mineral density, bone mineral content, and overall loss of bone strength in female mice. We, therefore, speculated that loss of TIEG1 expression would impair the actions of estrogen on bone in female mice. To test this hypothesis, we employed an ovariectomy (OVX) and estrogen replacement model system to comprehensively analyze the role of TIEG1 in mediating estrogen signaling in bone at the tissue, cell, and biochemical level. Dual-energy X-ray absorptiometry (DXA), peripheral quantitative computed tomography (pQCT), and micro-CT analyses revealed that loss of TIEG1 expression diminished the effects of estrogen throughout the skeleton and within multiple bone compartments. Estrogen exposure also led to reductions in bone formation rates and mineralizing perimeter in wild-type mice with little to no effects on these parameters in TIEG1 KO mice. Osteoclast perimeter per bone perimeter and resorptive activity as determined by serum levels of CTX-1 were differentially regulated after estrogen treatment in TIEG1 KO mice compared with wild-type littermates. No significant differences were detected in serum levels of P1NP between wild-type and TIEG1 KO mice. Taken together, these data implicate an important role for TIEG1 in mediating estrogen signaling throughout the mouse skeleton and suggest that defects in this pathway are likely to contribute to the sex-specific osteopenic phenotype observed in female TIEG1 KO mice.
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