ReviewHistology and histopathology2014
Molecular cues for development and regeneration of salivary glands.
Review in Histology and histopathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 30 citations in OpenAlex.
- Correlated Expression of Notch2 and ADAM17 in Primary Sjögren's Syndrome Salivary Glands.Journal of clinical medicine · 2025Article
- Salivary gland stem/progenitor cells: advancing from basic science to clinical applications.Cell regeneration (London, England) · 2025Review
- Notch1 down-regulation in lineage-restricted niches is involved in the development of mouse eccrine sweat glands.Journal of molecular histology · 2022Article
- Bioengineering in salivary gland regeneration.Journal of biomedical science · 2022Review
- Diagnosis, Prevention, and Treatment of Radiotherapy-Induced Xerostomia: A Review.Journal of oncology · 2022Review
- Sci-Seq of Human Fetal Salivary Tissue Introduces Human Transcriptional Paradigms and a Novel Cell Population.Frontiers in dental medicine · 2022Article
- Role of the hedgehog signaling pathway in rheumatic diseases: An overview.Frontiers in immunology · 2022Review
- Sclerosing Sialadenitis Is Associated With Salivary Gland Hypofunction and a Unique Gene Expression Profile in Sjögren's Syndrome.Frontiers in immunology · 2021Article
- Epithelial Cell Lineage and Signaling in Murine Salivary Glands.Journal of dental research · 2019Review
- Expression patterns of genes critical for SHH, BMP, and FGF pathways during the lumen formation of human salivary glands.Journal of molecular histology · 2019Article
- Comparing human and mouse salivary glands: A practice guide for salivary researchers.Oral diseases · 2019Review
- Article
- The role of stem cells in the prevention and treatment of radiation-induced xerostomia in patients with head and neck cancer.Cancer medicine · 2016Review
- The Link between Autoimmunity and Lymphoma: Does NOTCH Signaling Play a Contributing Role?Frontiers in oncology · 2015Review
- Extracellular matrix turnover in salivary gland disorders and regenerative therapies: Obstacles and opportunities.Journal of oral biology and craniofacial researchArticle
- Beta-catenin in disease.Journal of oral and maxillofacial pathology : JOMFPArticle
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
The hypofunction of salivary glands caused by Sjögren's Syndrome or radiotherapy for head and neck cancer significantly compromises the quality of life of millions patients. Currently no curative treatment is available for the irreversible hyposalivation, whereas regenerative strategies targeting salivary stem/progenitor cells are promising. However, the success of these strategies is constrained by the lack of insights on the molecular cues of salivary gland regeneration. Recent advances in the molecular controls of salivary gland morphogenesis provided valuable clues for identifying potential regenerative cues. A complicated network of signaling molecules between epithelia, mesenchyme, endothelia, extracellular matrix and innervating nerves orchestrate the salivary gland organogenesis. Here we discuss the roles of several cross-talking intercellular signaling pathways, i.e., FGF, Wnt, Hedgehog, Eda, Notch, Chrm1/HB-EGF and Laminin/Integrin pathways, in the development of salivary glands and their potentials to promote salivary regeneration.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.