Observational studyJournal of assisted reproduction and genetics2014
Correlation between follicular diameters and flushing versus no flushing on oocyte maturity, fertilization rate and embryo quality.
Observational study in Journal of assisted reproduction and genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Follicular flushing during oocyte retrieval in assisted reproductive techniques.The Cochrane database of systematic reviews · 2022Pooled it
- Follicular flushing during oocyte retrieval in assisted reproductive techniques.The Cochrane database of systematic reviews · 2018Pooled it
- Human recombinant follicle stimulating hormone (rFSH) compared to urinary human menopausal gonadotropin (HMG) for ovarian stimulation in assisted reproduction: a literature review and cost evaluation.Journal of endocrinological investigation · 2015Pooled it
- Determination of the optimal follicle size at the time of trigger in patients with diminished ovarian reserve undergoing ICSI cycle.Journal of ovarian research · 2025Article
- Single or Double-Lumen Aspiration Needle? Revisiting Choices for In Vitro Fertilization or Intracytoplasmic Sperm Injection-A Critical Review.Life (Basel, Switzerland) · 2025Review
- Impact of follicular size categories on oocyte quality at trigger day undergoing luteal phase stimulation protocol.Archives of gynecology and obstetrics · 2025Article
- Oocyte Competence, Embryological Outcomes and miRNA Signature of Different Sized Follicles from Poor Responder Patients.International journal of molecular sciences · 2024Article
- Progesterone levels on hCG day and oocyte maturation in a Mexican IVF program.JBRA assisted reproduction · 2024Observational
- Effect of the degree of follicular diameter ≥18mm differentiation on the day of hCG administration to the outcome of controlled ovarian hyperstimulation (COH).Frontiers in endocrinology · 2024Article
- The potential influence of follicle diameter on natural cycle in vitro fertilization among women with diminished ovarian reserve: a retrospective cohort study.Journal of ovarian research · 2023Article
- Impact of follicular size categories on oocyte quality at trigger day in young and advanced-age patients undergoing GnRH-ant therapy.Frontiers in endocrinology · 2023Article
- Increasing dominant follicular proportion negatively associated with good clinical outcomes in normal ovarian responders using the depot GnRH agonist protocol: a large-sample retrospective analysis.Journal of ovarian research · 2022Article
- Relationship between follicular size and developmental capacity of oocytes under controlled ovarian hyperstimulation in assisted reproductive technologies.Reproductive medicine and biology · 2021Article
- Causes and Effects of Oocyte Retrieval Difficulties: A Retrospective Study of 10,624 Cycles.Frontiers in endocrinology · 2021Article
- Using exosomal miRNAs extracted from porcine follicular fluid to investigate their role in oocyte development.BMC veterinary research · 2020Article
- Follicular flushing increases the number of oocytes retrieved in poor ovarian responders undergoing in vitro fertilization: a retrospective cohort study.BMC women's health · 2018Article
- Association of follicular fluid volume with membrane stretchability of human metaphase II oocytes following the gonadotropin-releasing hormone agonist protocol during intracytoplasmic sperm injection.Reproductive medicine and biology · 2018Article
- Follicle Size on Day of Trigger Most Likely to Yield a Mature Oocyte.Frontiers in endocrinology · 2018Article
- Anti-Mullerian hormone concentrations in individual follicular fluids within one stimulated IVF cycle resemble blood serum values.Journal of assisted reproduction and genetics · 2017Article
- The association of follicular fluid volume with human oolemma stretchability during intracytoplasmic sperm injection.Clinical and experimental reproductive medicine · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine (a) the correlation between follicular sizes, oocyte maturity, normal fertilization rate, cleavage and embryo quality; and (b) to establish whether oocytes recovered with or without follicular flushing have different developmental competence.
designProspective observational study.
settingAcademic medical center. PATIENTS: Forty nine cycles (37 ICSI and 12 IVF).
interventionsMeasurement of 360 follicular diameters on the day of egg retrieval and classification into three groups Group A (mean diameter 12-14.5 mm.), group B (mean diameter 15-18 mm.) and group C (diameter >18.5 mm.).
main outcome measureCorrelation between follicular size at the time of retrieval and oocyte maturity, fertilization and cleavage rate in 226 oocytes (163 ICSI and 63 IVF). Developmental competence of oocytes retrieved with flushing versus non flushing.
resultsAlmost all (99 %) of the oocytes recovered from follicles of group C were in metaphase II as opposed to 80 % in group A and 81 % in group B (p < 0.01). Overall there was a progressive and significant increase in fertilization rates from group A follicles to group C (47 % vs. 67 %, p 0.05). Overall 53 % of oocytes retrieved from group A follicles showed either no fertilization or abnormal fertilization versus 27 % in group C (p 0.05). The oocyte recovery rate with follicular flushing improved from group A to group B and to group C follicles (65 % vs. 49 % vs.37 % respectively p < 0.01). There were no differences in rates of immature oocyte, fertilization, abnormal or not fertilization and cleavage.
conclusionsThe results of this study shows that: a) Follicles larger than 18 mm at retrieval have consistently mature oocytes with a higher rate of fertilization; b) Small size follicles are still capable of containing mature oocytes, but their rate of abnormal or no fertilization is high; c) Oocytes recovered with flushing are still able to produce embryos with full developmental competence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.