ReviewNature reviews. Rheumatology2013
Immune mechanisms in medium and large-vessel vasculitis.
Review in Nature reviews. Rheumatology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02584517 (Understanding the Aetiology and Pathogenesis of Giant Cell Arteritis), which is not on this map. Cited by 183 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Understanding the Aetiology and Pathogenesis of Giant Cell Arteritis
Who cites it
183 citing papers in PubMed, 5 syntheses or guidelines pooled it, 410 citations in OpenAlex.
- Association between infection and the onset of giant cell arteritis and polymyalgia rheumatica: a systematic review and meta-analysis.RMD open · 2023Pooled it
- Norwegian society of rheumatology recommendations on diagnosis and treatment of patients with giant cell arteritis.Frontiers in medicine · 2022Pooled it
- A meta-analysis of the epidemiology of giant cell arteritis across time and space.Arthritis research & therapy · 2021Pooled it
- Analysis of the common genetic component of large-vessel vasculitides through a meta-Immunochip strategy.Scientific reports · 2017Pooled it
- A candidate gene approach identifies an IL33 genetic variant as a novel genetic risk factor for GCA.PloS one · 2014Pooled it
- The association of serum interleukin-6 levels with clinical outcomes in antineutrophil cytoplasmic antibody-associated vasculitis.Journal of autoimmunity · 2019Trial
- Aortitis as a High-Risk Vascular Syndrome: Integrating Phenotype-Driven Diagnosis, Multidisciplinary Assessment, and Personalised Management.Journal of personalized medicine · 2026Review
- Article
- Periodontal inflammation in patients with polymyalgia rheumatica.Irish journal of medical science · 2026Article
- Application of conventional ultrasound-based carotid grading system in assessing disease activity and monitoring progression in Takayasu arteritis.Clinical physiology and functional imaging · 2026Article
- Malignant renovascular hypertension consequent to IgA vasculitis in a young male patient: a case report.Journal of medical case reports · 2026Article
- Pathogenetic Gut Microbiota in Aortic Diseases: Evidence and Mechanisms Across Aneurysm, Dissection, and Inflammatory Aortopathies.Nutrients · 2026Review
- Genome-Wide DNA Methylation Study Reveals Specific Signatures in the Affected Arterial Tissue of Patients With Giant Cell Arteritis.Arthritis & rheumatology (Hoboken, N.J.) · 2026Article
- Phenotypic heterogeneity of giant cell arteritis in an Asian cohort: clinical, imaging, and laboratory characteristics.Frontiers in medicine · 2026Article
- Association between antibiotic use and the onset of giant cell arteritis and polymyalgia rheumatica: A nested case-control study from E3N-European Prospective Investigation into Cancer and Nutrition.Journal of internal medicine · 2025Article
- Monocytes/Macrophages in Giant Cell Arteritis-Polymyalgia Rheumatica Spectrum Disease.Aging and disease · 2025Review
- Uncovering the New Biology of Giant Cell Arteritis to Guide Therapeutic Strategies.Journal of clinical medicine · 2025Review
- Sustained immune youth risks autoimmune disease in the aging host.Nature aging · 2025Review
- Arterial and venous thrombosis in systemic and monogenic vasculitis.Nature reviews. Rheumatology · 2025Review
- Single-cell transcriptome analysis reveals cellular heterogeneity in the aortas of Takayasu arteritis.Arthritis research & therapy · 2025Article
123 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Vasculitis of the medium and large arteries, most often presenting as giant cell arteritis (GCA), is an infrequent, but potentially fatal, type of immune-mediated vascular disease. The site of the aberrant immune reaction, the mural layers of the artery, is strictly defined by vascular dendritic cells, endothelial cells, vascular smooth muscle cells and fibroblasts, which engage in an interaction with T cells and macrophages to, ultimately, cause luminal stenosis or aneurysmal wall damage of the vessel. A multitude of effector cytokines, all known as critical mediators in host-protective immunity, have been identified in vasculitic lesions. Two dominant cytokine clusters--the IL-6-IL-17 axis and the IL-12-IFN-γ axis--have been linked to disease activity. These two clusters seem to serve different roles in the vasculitic process. The IL-6-IL-17 cluster is highly responsive to standard corticosteroid therapy, whereas the IL-12-IFN-γ cluster is resistant to steroid-mediated immunosuppression. The information exchange between vascular and immune cells and stabilization of the vasculitic process involves members of the Notch receptor and ligand family. Focusing on elements in the tissue context of GCA, instead of broadly suppressing host immunity, might enable a more tailored therapeutic approach that avoids unwanted adverse effects of aggressive immunosuppression.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.